Introduction: The purpose of this study was to determine the effectiveness of Mindfulness-Based Cognitive Therapy and metacognitive therapy on psychological well-being, mental agility and resilience of mothers of children with cerebral palsy. The statistical population of this study included all mothers of children with cerebral palsy in North Khorasan Province in 2017 and 2018. Methods: Samples were selected by simple random sampling method (39 people) Then, they were randomly divided into two experimental groups (13 in the Mindfulness-Based Cognitive Therapy group and 13 in the metacognitive therapy group) and one in the control group (13 people). The pre-test was used from Reef Psychological Well-Being Questionnaire, Conner-Davidson Resilience Scale, Ryan's and Friedrich's mental regression scales. In the next step, the MindfulnessBased Cognitive Therapy and Metacognition Therapy in 8 sessions and once a week For two hours was performed on examination Group and control group didn’ t received any intervention. Then, the post-test was completed for all three groups. Eventually, after two months, all three groups were evaluated And the necessary data were collected And analyzed by repeated measures of variance analysis. Results: The results showed a significant difference between the two groups of metacognitive therapy and mindfulness-based cognitive therapy whit control group on the Variables of subjective well-being and Mental vitality. However, this difference was not significant in the resilient variable. Also, comparing Between the two treatments of mindfulness and metacognition on the present research variables, showed no significant difference between the two groups. Conclusions: According to the findings, in order to increase the level of psychological well-being and mental vitality of mothers of children with cerebral palsy, meta-cognitive and mindfulness training should be paid more attention.