Aim: Considering the vital role of professional resuscitators in advanced resuscitation and reducing the mortality rate of people with cardiopulmonary arrest, this article aims to present new advanced cardiopulmonary resuscitation. Information sources or data: In 2021, the study was searched in reputable databases and databases, including SID, Science of Web, Scopus, PubMed, and Scholar Google. Selection methods for study: This review study is based on the translation of the Heart Association's Cardiopulmonary Resuscitation Guide 2020 and other library resources and articles published by searching reputable databases between 2010 and 2020 using Boolean operators or with the keywords " Guidelines", "cardiac arrest", "advanced cardiac support" were performed. A total of 680 articles and 2 guidelines were found. After applying the inclusion and exclusion criteria, 19 articles and 1 guideline were finally reviewed. Combine content and results: The new guideline emphasizes post-cardiopulmonary resuscitation care as well as psychological support for paramedics, and the first to sixth stages of the survival chain include early detection and prevention, emergency contact, high-quality CPR, and defibrillation, respectively. In the new guide, the use of equipment and drugs and how specific cases are managed have been changed based on evidence and updated. Conclusion: Awareness of advanced cardiopulmonary resuscitation and its latest changes is necessary and evident for all professional resuscitators.