Regarding the importance of energy consumption and trade liberalization in economic growth, the effects of these two variables on GDP examined during the 2016-1995 for OPEC countries. First, the relationship between variables was evaluated with a panel vector autoregressive model. The results showed that there is a two-way causal relationship between the variables. Afterward, confirmed the presence of a causal relationship between the variables, the long-run and short-run relationship between variables was investigated with a panel co-integration approach. Results showed that energy consumption and trade liberalization had a significant effect on GDP in long-run. However, the role of trade liberalization in GDP growth was less important than energy consumption. Short-run results were similar to long-run but the error correction term represented the low-speed adjustment in this study.