A pot experiment was conducted based on a factorial study and complete random block design with threereplicates to investigate the phytoremediation potential of Sorghum biocilor L. in soils polluted with nickeland manganese during 2017-2018. The first factor was nickel nitrate (0, 60, and 120 mg kg-1 soil) and thesecond factor comprised of manganese sulphate (0, 50, and 100 μ M). The characteristics under investigationwere shoot height, root length, shoot dry weight, root dry weight, nickel concentration of shoots and roots, manganese concentration of shoots and roots, and nickel and manganese translocation factors. Findingssuggested that under nickel and manganese stress, shoot height, root length, shoot dry weight, and root dryweight reduced. Also, with an increase in the soil nickel and manganese, so did the concentration of theseheavy metals in roots and shoots of the plants under study. Maximum effect of nickel and manganese wererecorded in the treatments comprising 120 mg Kg-1 Nickel and 100 μ M manganese sulphate, respectivelywhile compared with nickel, manganese caused less damage to the plants under study. Application of nickelto the soil increased the translocation factor while there was no difference between the two levels of nickelapplied. On the other hand, application of manganese did not affect the translocation factor compared tothe control and the translocation factors for both elements were less than 1. Therefore, based on the findingsof the study, sorghum showed a relatively good tolerance to nickel and manganese, the absorbed nickel andmanganese were mostly concentrated in the plant root, and Sorghum biocilor L. is not recommended forphytoremediation.