Purpose: The aim of research is to determine demographic variables of librarians of comprehensive units of university libraries of Islamic Azad University, their relation and influence on entrepreneurship psychological characteristics from the viewpoint of humanistic school. Methodology: Research method is a survey and descriptive analytic survey. The research was based on the humanistic school with 26 entrepreneurship psychological characteristics. Total of statistical society were 109 librarians and questionnaire of self testing was used as a tool. The analysis of information was done by descriptive and analytic statistics by SPSS software.Findings: Entrepreneurship psychological characteristics in librarians was more than average point meaningfully and there was meaningful relationship between educational degree of library science and education level of librarians with their psychological characteristics. Also, among some of the psychological characteristics of librarians with educational degree variable and the level of educations had appositive and direct coefficient with increase of scores of scale of these variables, the entrepreneurship psychological characteristic of librarians increase. Among characteristics of librarians' entrepreneurship psychological, foresight characteristic receives the least influence and innovating characteristic receives the most influence from the demographic variables.Conclusion: With the existence of a few experts and knowledgeable in the field of entrepreneurship of librarians the findings of this research, is as a new approach in the study of characteristics of librarians entrepreneurship psychological. It is expected librarians could designate backgrounds for entrepreneurship activities in the libraries. Due to economical situation of the world and shortage of budget in the big trading centers, libraries still have a very valuable good and something that they can sell. This valuable good is information. Information is the primary exploitation and usage of information owe to absorption and use of librarians with entrepreneurship characteristics.