Many Qur'anic concepts, such as endurance, patience, steadfastness, jihad, martyrdom, victory, and Ihda al-Husnain (one of the good things), refer to Islamic resistance. Numerous verses are used to suggest that Islamic resistance is one of the most important strategies of the Islamic community in dealing with enemies. The extent of the verses has made it possible to examine and conduct research on Islamic resistance in the Holy Qur'an in various ways. The diversity of the enemy's methods in confronting Islam and Muslims in the contemporary period necessitates dealing with these issues. In the current study, with a descriptiveanalytical and library method, the role of believing in monotheism in Islamic resistance from the Quran's point of view is discussed. From the classification, study, and reflection on the verses of the Qur'an, it is concluded that most of the verses related to this subject are associated with the goals of monotheists and increase their motivation to resist and monotheism is an essential element of the Islamic resistance and the phenomenon of Islamic resistance is in many ways inextricably linked to monotheism.