Background: Female-headed households are one of the most important, sensitive and vulnerable groups in society whose health status is important for facilitating and policymaking. The aim of this study was to determinate the relationship between healthpromoting lifestyle and social well-being in female heads of suburban households of Karaj city. Materials and methods: Overall, 160 female-headed households of suburban of Karaj were selected by stratified random sampling method. Data were collected through the standard social well-being and Health-Promoting Lifestyle Profile (HPLP) questionnaires. Data analysis was performed using Pearson correlation, one-way analysis of variance (ANOVA) and multiple regression tests with a significance level of 5% by SPSS 22. 0. Results: The results showed a significant positive correlation between health-promoting lifestyle and social well-being in female-headed households of suburban (r = 0. 33, PValue <0. 01). Regression analysis showed that from subscales of the health-promoting lifestyle, interpersonal relationships (B = 0. 31, P-Value = 0. 014) and responsibility (B = 0. 27, P-Value = 0. 004) had the greatest impact on social well-being. Education level had a significant positive correlation with social well-being (r = 0. 18, P-Value = 0. 025) and health-promoting lifestyle (r = 0. 20, P-Value = 0. 01). Conclusion: Health-promoting lifestyle, especially sub-scale of interpersonal relationships affect the social well-being of female-headed households of suburban. Given that the education level of these women was very low, it is recommended to pay more attention to education, especially the learning of individual and social skills in these areas.