Background & Aims: Four principles of medical ethics, i.e. respect for autonomy, beneficial, nonmaleficience and justice have been attributed to general judgments. They were utilized and evaluated as unquestioned ethics through which man's act are being investigated. There are many discrepancies, such as determining the realm of freedom, and the independence of the individual who do not possess discernment in these codes, or they could be cases such at fetuses, infants, coma-patients, prisoners, etc that make doctors and medical teams face serious problems and doubt in decision making. Since the definition and the realm of these four principles differ when we compare different weltanschauungs, the system of the Islamic ethics should be justified accordingly. Having explained the principles, attempts have been made to measure the degree of consistency between these principles and the Islamic ethics and thoughts.Materials & Method: This research is descriptive and comparative. Having explained the similarities and differences as well as usages of the unquestioned principles, the research tries to explain and compare the principles and bases of Islamic ethics and thoughts.Result: Investigations of various ethical schools show that the principles and quadruple measures are obtained from utilitarianism whereas, the system of Islamic ethics is derived from teleology and deontologism. In this regard, these two systems (Islamic ethics and medical ethics) cover each other in some bases, while they are inconsistent in some other parts.Discussion: Since Islam is a teleological and deontological religion, the ultimate goal in its moral system is the welfare of man and getting closer to God. In this respect, man, from the divine religions' point of view, has two aspects: body and soul, and has a great place and dignity in the existence. So the reason of his existence is reaching his proper evolution and getting closer to his Lord. That is why; Islamic-medical ethics is in the framework whose parameters are elaborated in the structure of Islam.Accordingly, man is to consider the virtue of God, to observe his own responsibility before God, himself, and society. He has emphasized to use his efforts for the transcendence his spirit, the stages of his existence, intention, divine in motivation and spiritual pleasures. These variables would be the best guarantees for the ethical measures and principles in the domain of medical occupation. This therefore can free the medical team from doubt and decision making crises, the execution of research projects, and compensate the weakness of the other ethical schools which are based on human being's desires, mortal pleasures and the improvement of the medical life.