The Cultural reflection of Manichaeism can be vividly seen through the first centuries of Islamic era, the rejection of earthly life, the deny of materialities and paying only to the affairs of Another World, which are the main themes of Manichaeism, won the continuity through Islamic Mysticism and Gnosticism. The Gholat of the Shiite and Zanadaghe were among the sects impressed by Manichaeism. One can discover the motif of The Eternal Life through the Islamic gnostic exegesis, a motif which is the remainder of Manichaean belief in the Paradise of Light and the fall of Light from the transcendental firmaments to the earthly world. The religious, intellectual and cultural reflection of gnostics in Iran and Islamic world began in the late 3rd century A.D. and continued to the Ismaili intellectual movement. Islamic philosophers have used some of the idioms and themes of Manichaeism in their philosophic works. The Ismaili ascetics had also the main role in this movement.