Background and Aim: As the population of the world increases, it is essential that food production keep pace. It will be necessary not only to produce more food, but also to maintain this food so that it is safe and wholesome for human consumption. The purpose of this study was to investigate the rate of Coliform, Staphylococcus aurous, Mould, Yeast and other aerobic and mesophilic bacteria as contaminates of milk and milk products in Yazd province.Material and Methods: In this study a total of 198 different samples including Milk (24.2%), Yoghurt (21.2%), Cream (12.1%), Cheese (18.2%), Ice cream (12.1%) and dairy powders (12.1%) were investigated by culture method and biochemical tests. Then obtained data were analyzed by SPSS and X2 programs. Results: On the basis of our findings, of the total samples, 136 cases (68.7%) were desirable, 48 cases (24.2%) acceptable and 14 cases (7.1%) undesirable. Microbial contaminants of undesirable samples were coliform (7.1%), Staphylococcus aurous (6.1%) and yeast (6.1%). Meanwhile, the results of X2 Statistical analysis test, showed significant different between contamination rate and kind of Milk products (df = 5, X2 = 17.75, P<0.005).Conclusion: It seems that despite the efforts, which have been done for prevention of food contamination in Yazd province, it is still considered as a threat for people Health.