Cystic fibrosis is an inheritant autosomal recessive disease. It is associated with mutations in Cystic Fibrosis Trans Regulator gene (CFTR) and has different presentations. We report two 2 month old female patients, products of a twin delivery presented with anemia, edema, hypoalbuminemia and pneumonia. After some work ups, diagnosis of cystic fibrosis was confirmed. This is an uncommon and interesting presentation of cystic fibrosis, which occurred simultaneously in one twin.