THE INHIBITORY SYNERGISTIC EFFECTS OF VERAPAMIL AND SATUREJA HORTENSIS ESSENTIAL OIL ON CHOLINERGIC CONTRACTION OF RAT ILEUM

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HEJAZIAN S.H.; SAFARI F.; BAMERI M.

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Journal: IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS Year:2016 | Volume:31 | Issue:6 (74) Page(s): 1096-1103

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Title

THE INHIBITORY SYNERGISTIC EFFECTS OF VERAPAMIL AND SATUREJA HORTENSIS ESSENTIAL OIL ON CHOLINERGIC CONTRACTION OF RAT ILEUM

Author(s)

HEJAZIAN S.H. | SAFARI F. | BAMERI M. | Issue Writer Certificate

Keywords

VERAPAMILQ2

SATUREJA HORTENSIS L.Q2

ESSENTIAL OILQ2

SPASMOLYTHICQ2

ACETYLCHOLINEQ2

ILEUMQ2

SMOOTH MUSCLEQ2

Abstract

VERAPAMIL inhibits the cytosolic calcium content by blocking both activated and inactivated T-type calcium. Regarding the spasmolytic effect of materials caused by blockage of calcium channels and due to the inhibitory effect of SATUREJA HORTENSIS L. on ILEUM SMOOTH MUSCLE contraction. The present study was designed to find out the synergistic effects of calcium blocker VERAPAMIL and Satureja ESSENTIAL OIL on inhibition of cholinergic contraction in male rat’s ILEUM. In this study, by using an oscillographic device, the effects of different concentration of Satureja ESSENTIAL OIL and VERAPAMIL were examined on isotonic contraction of ILEUM induced by ACETYLCHOLINE10-4M. Our results showed that both VERAPAMIL and Satureja ESSENTIAL OILs inhibited ACETYLCHOLINE-induced contraction of ILEUM. In addition, their ineffective doses had synergistic spasmolytic effects, which were statistically significant (p<0.05).

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APA: Copy

HEJAZIAN, S.H., SAFARI, F., & BAMERI, M.. (2016). THE INHIBITORY SYNERGISTIC EFFECTS OF VERAPAMIL AND SATUREJA HORTENSIS ESSENTIAL OIL ON CHOLINERGIC CONTRACTION OF RAT ILEUM. IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS, 31(6 (74)), 1096-1103. SID. https://sid.ir/paper/104758/en

Vancouver: Copy

HEJAZIAN S.H., SAFARI F., BAMERI M.. THE INHIBITORY SYNERGISTIC EFFECTS OF VERAPAMIL AND SATUREJA HORTENSIS ESSENTIAL OIL ON CHOLINERGIC CONTRACTION OF RAT ILEUM. IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS[Internet]. 2016;31(6 (74)):1096-1103. Available from: https://sid.ir/paper/104758/en

IEEE: Copy

S.H. HEJAZIAN, F. SAFARI, and M. BAMERI, “THE INHIBITORY SYNERGISTIC EFFECTS OF VERAPAMIL AND SATUREJA HORTENSIS ESSENTIAL OIL ON CHOLINERGIC CONTRACTION OF RAT ILEUM,” IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS, vol. 31, no. 6 (74), pp. 1096–1103, 2016, [Online]. Available: https://sid.ir/paper/104758/en

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