PROTECTIVE EFFECT OF FLAVONOIDS, AGAINST RED BLOOD CELL HEMOLYSIS

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ASGARI SEDIGHEH; NADERI GHOLAM ALI; ASKARI NAZILA

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Paper Information

Journal: IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS Year:2006 | Volume:21 | Issue:4 (30) Page(s): 505-515

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Information Journal Paper

Title

PROTECTIVE EFFECT OF FLAVONOIDS, AGAINST RED BLOOD CELL HEMOLYSIS

Author(s)

ASGARI SEDIGHEH | NADERI GHOLAM ALI | ASKARI NAZILA | Issue Writer Certificate

Keywords

ANTIOXIDANTQ2

RUTINQ4

KAEMPFEROLQ3

QUERCETINQ3

MORINQ4

RBCQ4

-SH CAPACITYQ4

Abstract

Flavonoids which are polyphenolic substances are found in different vegetable and fruits and they have anti-oxidant properties. Epidemiological studies showed that flavonoids reduce the prevalence of cardiovascular disease. On the other hand, the usage of synthetic ANTIOXIDANTs has been limited because of their toxicity and, there are different researches to find better natural ANTIOXIDANTs. This survey investigates the effect of some pure flavonoids such as KAEMPFEROL, QUERCETIN, MORIN and RUTIN on red blood cell (RBC) hemolysis and their -SH CAPACITY as membrane protection indicator. The flavonoids solutions were prepared. Rate of RBC hemolysis and–SH capacity of cell membrane were determined by spectrophotometer. 2,2 azobis2 amidino propane dihydrechloride (AAPH) was used to induce RBC peroxidation. The effect of each flavonoids on RBC hemolysis was examined in 3 concentrations (0.15, 5, 10) mg/ml but for investigating the effect on -SH groups only the highest concentration (10 mg/ml) of each flavonoids were used. In all cases, the ANTIOXIDANT activity was dose dependent. RUTIN showed the highest inhibitory effect on RBC hemolysis than other flavonoid, that was 42.5. Also KAEMPFEROL, RUTIN, MORIN protect-SH groups 6%, 23.3%, 26.4% respectively. Results showed that flavonoids and plants contain flavonoids can be used as natural ANTIOXIDANTs for treatment and prevention of diseases which their pathogenesis is lipid peroxidation.

Cites

SALINITY AND DROUGHT STRESS EFFECTS ON FLOWER YIELD AND FLAVONOL-O- GLYCOSIDES IN CHAMOMILE (MATRICARIA CHAMOMILLA L.)

References

PROTECTIVE EFFECT OF ACHILLEA MILLEFOLIUM, CRATAEGUS CURVISEPALA AND MATRICARIA CHAMOMILLA ON OXIDATIVE HEMOLYSIS OF HUMAN ERYTHROCYTES AND - SH CAPACITY.

Cite

APA: Copy

ASGARI, SEDIGHEH, NADERI, GHOLAM ALI, & ASKARI, NAZILA. (2006). PROTECTIVE EFFECT OF FLAVONOIDS, AGAINST RED BLOOD CELL HEMOLYSIS. IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS, 21(4 (30)), 505-515. SID. https://sid.ir/paper/105181/en

Vancouver: Copy

ASGARI SEDIGHEH, NADERI GHOLAM ALI, ASKARI NAZILA. PROTECTIVE EFFECT OF FLAVONOIDS, AGAINST RED BLOOD CELL HEMOLYSIS. IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS[Internet]. 2006;21(4 (30)):505-515. Available from: https://sid.ir/paper/105181/en

IEEE: Copy

SEDIGHEH ASGARI, GHOLAM ALI NADERI, and NAZILA ASKARI, “PROTECTIVE EFFECT OF FLAVONOIDS, AGAINST RED BLOOD CELL HEMOLYSIS,” IRANIAN JOURNAL OF MEDICINAL AND AROMATIC PLANTS, vol. 21, no. 4 (30), pp. 505–515, 2006, [Online]. Available: https://sid.ir/paper/105181/en

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