PREPARING AND CHARACTERIZING CHITOSAN NANOPARTICLES CONTAINING HEMISCORPIUS LEPTURUS SCORPION VENOM AS AN ANTIGEN DELIVERY SYSTEM

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHAMMADPOUR DOUNIGHI N.; DAMAVANDI M.; ZOLFAGHARIAN H.; MORADI S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: ARCHIVES OF RAZI INSTITUTE Year:2012 | Volume:67 | Issue:2 Page(s): 145-153

Download Full-Text

Persian Verion

View:

976

Download:

444

Cites:

Information Journal Paper

Title

PREPARING AND CHARACTERIZING CHITOSAN NANOPARTICLES CONTAINING HEMISCORPIUS LEPTURUS SCORPION VENOM AS AN ANTIGEN DELIVERY SYSTEM

Author(s)

MOHAMMADPOUR DOUNIGHI N. | DAMAVANDI M. | ZOLFAGHARIAN H. | MORADI S. | Issue Writer Certificate

Keywords

CHITOSANQ3

NANOPARTICLEQ3

VENOMQ3

IONIC GELATIONQ3

Abstract

In recent years, CHITOSAN NANOPARTICLEs have been studied widely for protein delivery. In this study, Hemiscorpius lepturus (HL) VENOM was encapsulated in CHITOSAN NANOPARTICLEs. The aim of the present work was to carry out a systematic study for preparing biocompatible and biodegradable NANOPARTICLEs for loading HL scorpion VENOM and to evaluate their potential as an antigen delivery system. In this study, HL VENOM loaded CHITOSAN NANOPARTICLEs fabricated by IONIC GELATION of CHITOSAN and tripolyphosphate and the factors which may be influenced in the preparation of NANOPARTICLEs were analyzed. Also, their physicochemical properties and in vitro release behavior were studied. The optimum encapsulation efficiency and capacity were observed when the CHITOSAN concentration and HL VENOM were 2 mg/ml and 500 mg/ml, respectively. The HL VENOM loaded NANOPARTICLEs were in the size range of 130-160 nm (polydispersity index values of 0.423) and exhibited the positive zeta potential. Transmission electron microscope imaging showed spherical and smooth surface of NANOPARTICLEs. The profiles of the release exhibited a burst releases about 50% in the first 4 hr and then slowed down at a constant rate. The obtained results suggested that the CHITOSAN NANOPARTICLEs prepared in this work had the potential for antigen delivery.

Cites

No record.

References

No record.

Cite

APA: Copy

MOHAMMADPOUR DOUNIGHI, N., DAMAVANDI, M., ZOLFAGHARIAN, H., & MORADI, S.. (2012). PREPARING AND CHARACTERIZING CHITOSAN NANOPARTICLES CONTAINING HEMISCORPIUS LEPTURUS SCORPION VENOM AS AN ANTIGEN DELIVERY SYSTEM. ARCHIVES OF RAZI INSTITUTE, 67(2), 145-153. SID. https://sid.ir/paper/120114/en

Vancouver: Copy

MOHAMMADPOUR DOUNIGHI N., DAMAVANDI M., ZOLFAGHARIAN H., MORADI S.. PREPARING AND CHARACTERIZING CHITOSAN NANOPARTICLES CONTAINING HEMISCORPIUS LEPTURUS SCORPION VENOM AS AN ANTIGEN DELIVERY SYSTEM. ARCHIVES OF RAZI INSTITUTE[Internet]. 2012;67(2):145-153. Available from: https://sid.ir/paper/120114/en

IEEE: Copy

N. MOHAMMADPOUR DOUNIGHI, M. DAMAVANDI, H. ZOLFAGHARIAN, and S. MORADI, “PREPARING AND CHARACTERIZING CHITOSAN NANOPARTICLES CONTAINING HEMISCORPIUS LEPTURUS SCORPION VENOM AS AN ANTIGEN DELIVERY SYSTEM,” ARCHIVES OF RAZI INSTITUTE, vol. 67, no. 2, pp. 145–153, 2012, [Online]. Available: https://sid.ir/paper/120114/en

Related Journal Papers