Effect of Local Transplantation of Bone Marrow Derived Mast Cells (BMMCs) Combined with Chitosan Biofilm on Excisional and Incisional Wound Healing: A Novel Preliminary Animal Study on Lamb

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GHORBANI ANAHITA; MOHAMMADI RAHIM; SHAHROOZ RASOUL

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Journal: Iranian Journal of Veterinary Surgery Year:2019 | Volume:14 | Issue:1 (30) Page(s): 34-43

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Information Journal Paper

Title

Effect of Local Transplantation of Bone Marrow Derived Mast Cells (BMMCs) Combined with Chitosan Biofilm on Excisional and Incisional Wound Healing: A Novel Preliminary Animal Study on Lamb

Author(s)

GHORBANI ANAHITA | MOHAMMADI RAHIM | SHAHROOZ RASOUL | Issue Writer Certificate

Keywords

Wound healingQ2

ExcisionalQ1

IncisionalQ1

BMMCsQ1

LambQ2

Abstract

Objective: To determine the effects of bone marrow derived mast cells (BMMCs) on Excisional and Incisional Wound healing in an animal model on Lamb. Design-Experimental Study Animals-Twelve healthy male Lambs Procedures-Animals were randomized into four groups of three animals each. In control animals, the created wounds were left untreated receiving 100 μ L PBS. In BMMC group, the created wounds were treated with 100 μ L BMMCs (2×106 cells/100 μ L) aliquots, injected into margins of the wounds. In chitosan group the created wounds were dressed with chitosan biofilm. In BMMC/chitosan group the created wounds were treated with 100 μ L BMMCs (2×106 cells/100 μ L) aliquots and dressed with chitosan biofilm. In Excisional wound model, planimetric studies were carried out to determine wound area reduction. In Incisional wound model, biomechanical studies were carried out to indirectly determine structural organization of the healing wound. Results-BMMC/chitosan group showed significantly earlier wound closure compared to other groups (p=0. 001). The biomechanical findings indicated that the parameters were significantly improved in the BMMC/chitosan group compared to other experimental groups (p=0. 001). Conclusion and clinical relevance-BMMCs local transplantation could be considered as a readily accessible source of cells that could improve Wound healing.

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APA: Copy

GHORBANI, ANAHITA, MOHAMMADI, RAHIM, & SHAHROOZ, RASOUL. (2019). Effect of Local Transplantation of Bone Marrow Derived Mast Cells (BMMCs) Combined with Chitosan Biofilm on Excisional and Incisional Wound Healing: A Novel Preliminary Animal Study on Lamb. IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS), 14(1 (30) ), 34-43. SID. https://sid.ir/paper/135701/en

Vancouver: Copy

GHORBANI ANAHITA, MOHAMMADI RAHIM, SHAHROOZ RASOUL. Effect of Local Transplantation of Bone Marrow Derived Mast Cells (BMMCs) Combined with Chitosan Biofilm on Excisional and Incisional Wound Healing: A Novel Preliminary Animal Study on Lamb. IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS)[Internet]. 2019;14(1 (30) ):34-43. Available from: https://sid.ir/paper/135701/en

IEEE: Copy

ANAHITA GHORBANI, RAHIM MOHAMMADI, and RASOUL SHAHROOZ, “Effect of Local Transplantation of Bone Marrow Derived Mast Cells (BMMCs) Combined with Chitosan Biofilm on Excisional and Incisional Wound Healing: A Novel Preliminary Animal Study on Lamb,” IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS), vol. 14, no. 1 (30) , pp. 34–43, 2019, [Online]. Available: https://sid.ir/paper/135701/en

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