Evaluation of Possible Beneficial Effect of Tricalcium Phosphate/Collagen (TCP/Collagen) Nanocomposite Scaffold on Bone Healing in Rabbits: Biochemical Assessments

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Farahi Hanieh; Mashhadi Rafie siamak; Jahandideh Alireza; ASGHARI AHMAD; SHIRAZI BEHESHTIHA SEYED HAMED

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Journal: Iranian Journal of Veterinary Surgery Year:2019 | Volume:14 | Issue:2 (31) Page(s): 162-172

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Title

Evaluation of Possible Beneficial Effect of Tricalcium Phosphate/Collagen (TCP/Collagen) Nanocomposite Scaffold on Bone Healing in Rabbits: Biochemical Assessments

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Keywords

ReconstructionQ1

bone healingQ1

TCP/collagen nanocompositeQ1

BiochemistryQ2

RabbitQ2

Abstract

Objective-The aim of this study was to evaluate possible beneficial effect of tricalcium phosphate/collagen (TCP/collagen) nanocomposite scaffold on bone healing in Rabbits using biochemical assessments Design-Experimental study Animals-Eighteen healthy male white New Zealand Rabbits Procedures-The Rabbits were marked with non-toxic color and randomly divided into two groups of 9 animals each. In the first group (Sham) the defect was made and with no treatment, the wound was closed. In the second group (TCP/C) the TCP/collagen nanocomposite scaffold was implanted into the defect. Before the procedures (day 0) and on 7, 15, 30, 45, and 60 postoperative days the blood samples were taken from the jugular vein and undergone hematological and biochemical assessments. Results-The hematological, biochemical and oxidative stress parameters including WBC, RBC, HCT, PLT, neutrophil, lymphocytes, BUN, Creatinine, AST, ALT, ALP, SOD, GPX and MDA showed statistically significant differences between Sham and TCP/C groups (p<0. 05). Conclusion and clinical relevance-It was concluded that TCP/collagen nanocomposite improved the biochemical parameters in the nanocomposite treated animals and could be of clinical benefit in Reconstruction of bone defects and could be considered as a scaffold in bone fractures.

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APA: Copy

Farahi, Hanieh, Mashhadi Rafie, siamak, Jahandideh, Alireza, ASGHARI, AHMAD, & SHIRAZI BEHESHTIHA, SEYED HAMED. (2019). Evaluation of Possible Beneficial Effect of Tricalcium Phosphate/Collagen (TCP/Collagen) Nanocomposite Scaffold on Bone Healing in Rabbits: Biochemical Assessments. IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS), 14(2 (31) ), 162-172. SID. https://sid.ir/paper/135726/en

Vancouver: Copy

Farahi Hanieh, Mashhadi Rafie siamak, Jahandideh Alireza, ASGHARI AHMAD, SHIRAZI BEHESHTIHA SEYED HAMED. Evaluation of Possible Beneficial Effect of Tricalcium Phosphate/Collagen (TCP/Collagen) Nanocomposite Scaffold on Bone Healing in Rabbits: Biochemical Assessments. IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS)[Internet]. 2019;14(2 (31) ):162-172. Available from: https://sid.ir/paper/135726/en

IEEE: Copy

Hanieh Farahi, siamak Mashhadi Rafie, Alireza Jahandideh, AHMAD ASGHARI, and SEYED HAMED SHIRAZI BEHESHTIHA, “Evaluation of Possible Beneficial Effect of Tricalcium Phosphate/Collagen (TCP/Collagen) Nanocomposite Scaffold on Bone Healing in Rabbits: Biochemical Assessments,” IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS), vol. 14, no. 2 (31) , pp. 162–172, 2019, [Online]. Available: https://sid.ir/paper/135726/en

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