In vivo assessment of anti-tumor activity of Methyl 2'-Methyl-1, 3-dioxo-1, 1', 2', 3, 5', 6', 7', 7a'-octahydrospiro[indene-2, 3'-pyrrolizidine]-2' carboxylate (6) on 7, 12 dimethylbenz(a) anthracene-induced mammary tumors in rat

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ZAREI LEILA; Kuhkan Mehri; Bolouri Ali; MOHAMMADI RAHIM

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Journal: Iranian Journal of Veterinary Surgery Year:2017 | Volume:12 | Issue:2 (27) Page(s): 53-62

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Title

In vivo assessment of anti-tumor activity of Methyl 2'-Methyl-1, 3-dioxo-1, 1', 2', 3, 5', 6', 7', 7a'-octahydrospiro[indene-2, 3'-pyrrolizidine]-2' carboxylate (6) on 7, 12 dimethylbenz(a) anthracene-induced mammary tumors in rat

Author(s)

ZAREI LEILA | Kuhkan Mehri | Bolouri Ali | MOHAMMADI RAHIM | Issue Writer Certificate

Keywords

Breast carcinogenesis;7Q1

12-Dimethylbenz(a)anthraceneQ1

Indene-2Q1

3'-pyrrolizidineQ1

mammary tumorsQ1

Abstract

Objective-Breast cancer is one of the most serious problems in oncology. Alkaloids pyrrolizidine are widely found in nature and exhibited versatile biological activities. The aim of the present study was to assess anti-tumor activity of methyl 1, 3-dioxo-1, 1', 2', 3, 5', 6', 7', 7a'-octahydrospiro[Indene-2, 3'-pyrrolizidine]-2'-carboxylate (6) on 7, 12 dimethylbenz(a) anthracene (DMBA)-induced mammary tumors in rat. Design-Experimental Study. Animals-Twenty-one female Wistar rats Procedures-7-Week-old female Wistar rats (180 g body weight) were randomized into three groups of seven animals each. DMBAinduced mammary tumors was achieved using DMBA dissolved in 1ml of vehicle (0. 5 ml of DMSO plus 0. 5 ml of saline) and injected by subcutaneous injection beneath the mammary gland on either side. Tumor yield and size were stabilized after 90 days with the initiation of DMBA. Healthy intact animals (NC) were considered as a normal control feeding on pellets and tap water. In group DMBA, the tumor was induced by DMBA. In group DMBA/6 the animals with tumor received 100 μ L 6 dissolved in DMSO (0. 25 μ M) solution interaperitoneally for one week. Synthesis of 6 was accomplished and the structure of new product was assigned by their 1H/13C NMR, IR, CH-COSY and mass spectral data as well as the elemental analysis. Results-The overall tumor analysis showed that 6 treatment significantly inhibited the breast tumor incidence, tumor multiplicity, and tumor size in the DMBA-initiated rat model. 6 treatment significantly inhibited the total volume of tumors per rat. Conclusion and Clinical Relevance-The findings of the present study showed that the 6 treatment was significantly effective in reduction of tumors versus the cancer controls.

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References

Pharmacological Potential and Synthetic Approaches of Imidazo[4, 5-b]pyridine and Imidazo[4, 5-c]pyridine Derivatives

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APA: Copy

ZAREI, LEILA, Kuhkan, Mehri, Bolouri, Ali, & MOHAMMADI, RAHIM. (2017). In vivo assessment of anti-tumor activity of Methyl 2'-Methyl-1, 3-dioxo-1, 1', 2', 3, 5', 6', 7', 7a'-octahydrospiro[indene-2, 3'-pyrrolizidine]-2' carboxylate (6) on 7, 12 dimethylbenz(a) anthracene-induced mammary tumors in rat. IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS), 12(2 (27) ), 53-62. SID. https://sid.ir/paper/135750/en

Vancouver: Copy

ZAREI LEILA, Kuhkan Mehri, Bolouri Ali, MOHAMMADI RAHIM. In vivo assessment of anti-tumor activity of Methyl 2'-Methyl-1, 3-dioxo-1, 1', 2', 3, 5', 6', 7', 7a'-octahydrospiro[indene-2, 3'-pyrrolizidine]-2' carboxylate (6) on 7, 12 dimethylbenz(a) anthracene-induced mammary tumors in rat. IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS)[Internet]. 2017;12(2 (27) ):53-62. Available from: https://sid.ir/paper/135750/en

IEEE: Copy

LEILA ZAREI, Mehri Kuhkan, Ali Bolouri, and RAHIM MOHAMMADI, “In vivo assessment of anti-tumor activity of Methyl 2'-Methyl-1, 3-dioxo-1, 1', 2', 3, 5', 6', 7', 7a'-octahydrospiro[indene-2, 3'-pyrrolizidine]-2' carboxylate (6) on 7, 12 dimethylbenz(a) anthracene-induced mammary tumors in rat,” IRANIAN JOURNAL OF VETERINARY SURGERY (IJVS), vol. 12, no. 2 (27) , pp. 53–62, 2017, [Online]. Available: https://sid.ir/paper/135750/en

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