EFFECT OF CURCUMIN ON MORPHINE-INDUCED ANTINOCICEPTION IN ACUTE CORNEAL PAIN IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAMADONFARD E.; HAMZEH GHOUSHCHI F.; HAMZEH GHOUSHCHI NASRIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Veterinary Medicine Year:2010 | Volume:4 | Issue:2 Page(s): 127-131

Download Full-Text

Persian Verion

View:

999

Download:

209

Cites:

Information Journal Paper

Title

EFFECT OF CURCUMIN ON MORPHINE-INDUCED ANTINOCICEPTION IN ACUTE CORNEAL PAIN IN RATS

Author(s)

TAMADONFARD E. | HAMZEH GHOUSHCHI F. | HAMZEH GHOUSHCHI NASRIN | Issue Writer Certificate

Keywords

CURCUMINQ3

MORPHINEQ3

NALOXONEQ3

ACUTE CORNEAL PAINQ3

RATSQ3

Abstract

In the present study, the effects of the acute and chronic oral administrations (po) of CURCUMIN in the absence and presence of MORPHINE and NALOXONE was investigated on the sensation of ACUTE CORNEAL PAIN in RATS. ACUTE CORNEAL PAIN was induced by the local application of hypertonic saline (5 M NaCl) on the corneal surface, and the number of eye wipes was then counted for 30 s. Subcutaneous (sc) injections of MORPHINE (1, 2 and 4 mg/kg) significantly suppressed corneal pain (p<0.05). NALOXONE (2 mg/kg, sc) did not change the intensity of pain when used alone, but pretreatment of the rates with NALOXONE (2 mg/kg, sc) significantly prevented the antinociceptive effect induced by MORPHINE (2 mg/kg, sc, p<0.05). The short-term and long-term oral administration of CURCUMIN (either a single dose of 200 mg/kg or dosages of 6.25, 12.5 of 25 mg/kg for 15 days each, respectively) both significantly decreased the number of eye wipes (p<0.05). The antinociceptive effect induced by MORPHINE was significantly (p<0.05) enhanced by both the acute (200 mg/kg, once, po) and chronic (25 mg/kg, 15 days, po) CURCUMIN treatments. NALOXONE (2 mg/kg, sc) did not change the antinociception that was induced by acute (200 mg/kg, once, po) and chronic (25 mg/kg, 15 days, po) treatments of CURCUMIN. The present findings suggest that MORPHINE produced an analgesic effect through a NALOXONE-sensitive mechanism in ACUTE CORNEAL PAIN. Both high-dose acute and lower-dose chronic oral administrations of CURCUMIN suppressed corneal pain. Moreover, CURCUMIN enhanced MORPHINE-induced antinociception.

Cites

No record.

References

No record.

Cite

APA: Copy

TAMADONFARD, E., HAMZEH GHOUSHCHI, F., & HAMZEH GHOUSHCHI, NASRIN. (2010). EFFECT OF CURCUMIN ON MORPHINE-INDUCED ANTINOCICEPTION IN ACUTE CORNEAL PAIN IN RATS. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), 4(2), 127-131. SID. https://sid.ir/paper/157916/en

Vancouver: Copy

TAMADONFARD E., HAMZEH GHOUSHCHI F., HAMZEH GHOUSHCHI NASRIN. EFFECT OF CURCUMIN ON MORPHINE-INDUCED ANTINOCICEPTION IN ACUTE CORNEAL PAIN IN RATS. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH)[Internet]. 2010;4(2):127-131. Available from: https://sid.ir/paper/157916/en

IEEE: Copy

E. TAMADONFARD, F. HAMZEH GHOUSHCHI, and NASRIN HAMZEH GHOUSHCHI, “EFFECT OF CURCUMIN ON MORPHINE-INDUCED ANTINOCICEPTION IN ACUTE CORNEAL PAIN IN RATS,” IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), vol. 4, no. 2, pp. 127–131, 2010, [Online]. Available: https://sid.ir/paper/157916/en

Related Journal Papers