BETAINE AS A METHYL DONOR AND AN ANTIOXIDANT AGENT IN LEVODOPA-INDUCED HYPERHOMOCYSTEINEMIA AND OXIDATIVE STRESS IN RAT'S KIDNEY

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ALIREZAEI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Journal of Veterinary Medicine Year:2014 | Volume:8 | Issue:2 Page(s): 91-99

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Title

BETAINE AS A METHYL DONOR AND AN ANTIOXIDANT AGENT IN LEVODOPA-INDUCED HYPERHOMOCYSTEINEMIA AND OXIDATIVE STRESS IN RAT'S KIDNEY

Author(s)

ALIREZAEI M. | Issue Writer Certificate

Keywords

BENSERAZIDEQ2

BETAINEQ2

HOMOCYSTEINEQ1

KIDNEYQ2

LEVODOPAQ2

Abstract

BACKGROUND: BETAINE has been shown to be antioxidant and methyl donor effects in our recent studies.OBJECTIVES: In the present study, the antioxidant and methyl donor properties of BETAINE in LEVODOPA/BENSERAZIDE-mediated hyperhomocysteinemia and LEVODOPA-induced oxidative stress in rat's KIDNEY were examined.METHODS: Sprague-Dawley male rats were divided into LEVODOPA (LD), BETAINE (Bet.), LEVODOPA plus BETAINE (LD/Bet.), LEVODOPA plus BENSERAZIDE (LD/Ben.), LEVODOPA plus BETAINE-BENSERAZIDE (LD/Bet.-Ben.), and control groups. The experimental groups received LD (3×100 mg/kg), Bet. (1.5% w/w of the total diet), Ben. (3×25 mg/kg), and distilled water was given to controls for 10 consecutive days, orally by gavage.RESULTS: Plasma total HOMOCYSTEINE (tHcy) concentration decreased significantly in Bet.-, LD/Bet.-, and LD/Bet.-Ben.-treated rats compared to LD/Ben. group. Thiobarbituric acid reactive substances concentration (as a lipid peroxidation marker) in renal tissue reduced statistically in BETAINE group in comparison with LD and LD/Ben. groups. Renal catalase activity increased significantly in LD-treated rats when compared to controls. Renal superoxide dismutase activity significantly decreased in LD-treated group when compared to LD/Ben. group. However, there was not any significant difference in renal glutathione peroxidase (GPx) activity among the groups.CONCLUSIONS: These findings indicate that LD and LD/Ben. have side effects in KIDNEY due to induction of hyperhomocysteinemia and oxidative stress. In contrast, BETAINE acts as a promising antioxidant and methyl donor agent versus LD-induced complications.

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APA: Copy

ALIREZAEI, M.. (2014). BETAINE AS A METHYL DONOR AND AN ANTIOXIDANT AGENT IN LEVODOPA-INDUCED HYPERHOMOCYSTEINEMIA AND OXIDATIVE STRESS IN RAT'S KIDNEY. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), 8(2), 91-99. SID. https://sid.ir/paper/157922/en

Vancouver: Copy

ALIREZAEI M.. BETAINE AS A METHYL DONOR AND AN ANTIOXIDANT AGENT IN LEVODOPA-INDUCED HYPERHOMOCYSTEINEMIA AND OXIDATIVE STRESS IN RAT'S KIDNEY. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH)[Internet]. 2014;8(2):91-99. Available from: https://sid.ir/paper/157922/en

IEEE: Copy

M. ALIREZAEI, “BETAINE AS A METHYL DONOR AND AN ANTIOXIDANT AGENT IN LEVODOPA-INDUCED HYPERHOMOCYSTEINEMIA AND OXIDATIVE STRESS IN RAT'S KIDNEY,” IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), vol. 8, no. 2, pp. 91–99, 2014, [Online]. Available: https://sid.ir/paper/157922/en

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