TiO2 Nanoparticles as a Common Component of Sunscreens: An Experimental Study of Dermal/Ocular Safety Assessment

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Jafari Seyedeh Maedeh; Sadeghi Hashgjin Goudarz; KOOHI MOHAMMAD KAZEM; Rassouli Ali; SHAHROOZIAN EBRAHIM

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Journal: Iranian Journal of Veterinary Medicine Year:2019 | Volume:13 | Issue:1 Page(s): 79-86

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Title

TiO2 Nanoparticles as a Common Component of Sunscreens: An Experimental Study of Dermal/Ocular Safety Assessment

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Keywords

Dermal irritationQ1

Eye irritationQ1

OECDQ1

Skin sensitizationQ1

TiO2-NPsQ1

Abstract

BACKGROUND: The safety evaluations of sunscreens containing Titanium Dioxide-Nanoparticles (TiO2-NPs) were done by dermal exposure, acute dermal and Eye irritation/corrosion, and Skin sensitization according to the guideline for Organization for Economic Co-operation and Development (OECD). OBJECTIVES: The aim of our study was the evaluation of safety and toxicity of TiO2-NPs following acute sunscreen exposure. METHODS: TiO2 and TiO2-NPs (20-40 nm and 98% purity) were purchased in the anatase crystal phase, and five types of concentration for sunscreens were made which were carried out in five different treatment groups in mice and rabbits. RESULTS: In acute Eye irritation using rabbits, the only irritation effect was observed in the conjunctivae area within one hour after administration both in TiO2-NPs group and TiO2-Ps. In acute Dermal irritation using rabbits did not show a significant difference among groups in different concentrations and durations. Similarly, in a Skin sensitization test using mice, contact hypersensitivity (CHS) did not show a significant difference (P<0. 05) among groups in 15% concentration of TiO2 in the different durations after application. CONCLUSIONS: Our finding demonstrates that TiO2-NPs and TiO2-Ps in sunscreens are relatively safe and did not induce statistically significant eye and Dermal irritation and skin hypersensitivity.

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APA: Copy

Jafari, Seyedeh Maedeh, Sadeghi Hashgjin, Goudarz, KOOHI, MOHAMMAD KAZEM, Rassouli, Ali, & SHAHROOZIAN, EBRAHIM. (2019). TiO2 Nanoparticles as a Common Component of Sunscreens: An Experimental Study of Dermal/Ocular Safety Assessment. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), 13(1 ), 79-86. SID. https://sid.ir/paper/158042/en

Vancouver: Copy

Jafari Seyedeh Maedeh, Sadeghi Hashgjin Goudarz, KOOHI MOHAMMAD KAZEM, Rassouli Ali, SHAHROOZIAN EBRAHIM. TiO2 Nanoparticles as a Common Component of Sunscreens: An Experimental Study of Dermal/Ocular Safety Assessment. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH)[Internet]. 2019;13(1 ):79-86. Available from: https://sid.ir/paper/158042/en

IEEE: Copy

Seyedeh Maedeh Jafari, Goudarz Sadeghi Hashgjin, MOHAMMAD KAZEM KOOHI, Ali Rassouli, and EBRAHIM SHAHROOZIAN, “TiO2 Nanoparticles as a Common Component of Sunscreens: An Experimental Study of Dermal/Ocular Safety Assessment,” IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), vol. 13, no. 1 , pp. 79–86, 2019, [Online]. Available: https://sid.ir/paper/158042/en

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