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Information Journal Paper

Title

Evaluation of anti-inflammatory effects of methanolic extract of Persian Gulf sea cucumber (Holothuria leucospilota) on rats (Rattus rattus)

Pages

  91-100

Abstract

 Sea Cucumber is one of the most important species of Echinodermata, belongs to the category of Holothuroidea. Their well-known bioactive compounds have anti-cancer, anticoagulant, antihypertensive, Anti-Inflammatory, antimicrobial, antioxidant, anti-arterial, and wound-healing effects. In this study, the antiinflammatory effect of methanolic extract on the muscular body wall of Sea Cucumbers Holothuria leucospilota on Albino rats was investigated. Sea Cucumbers were collected from the Hengam Island, dried and extracted with hexane, ethyl acetate and methanol. The extracts were evaluated by lipoxygenase enzymes inhibition test in in vitro conditions. In in vivo experiments, the animals were divided into 5 groups of 6 rats, including: control, treated with Carrageenan, treated with MEHL extract (100/200 mg / kg) and aspirin 10 mg/kg. In order to evaluate the inflammation, Carrageenan test was used in Hind paw edema method. In in vitro experiments, methanolic extract (MEHL) with 43. 75± 2. 83 and ethyl acetate and hexane extract showed 12. 92 ± 1. 22 and 9. 74 1. 57 percent inhibition of lipoxygenase enzymes, respectively. Methanolic extract (MEHL) Holothuria leucospilota was selected for further in vivo testing. In animal experiments, MEHL, with concentrations of 100 and 200 mg/kg, inhibited hind paw edema at 3 and 4 hours, with 13. 62 ± 1. 3 and 35. 15 ± 2. 5 and, 18. 41 ± 1. 7 and 45. 22 ± 3. 2 percent, respectively. Holothuria leucospilota methanolic extract contains antiinflammatory compounds that have shown better Anti-Inflammatory effects compared to the Anti-Inflammatory drug acetylsalicylic acid.

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    APA: Copy

    GHAFARI, HADI, MORADI, YAZDAN, NAZEMI, MELIKA, & SAFARI, REZA. (2020). Evaluation of anti-inflammatory effects of methanolic extract of Persian Gulf sea cucumber (Holothuria leucospilota) on rats (Rattus rattus). JOURNAL OF FISHERIES (IRANIAN JOURNAL OF NATURAL RESOURCES), 73(1 ), 91-100. SID. https://sid.ir/paper/161933/en

    Vancouver: Copy

    GHAFARI HADI, MORADI YAZDAN, NAZEMI MELIKA, SAFARI REZA. Evaluation of anti-inflammatory effects of methanolic extract of Persian Gulf sea cucumber (Holothuria leucospilota) on rats (Rattus rattus). JOURNAL OF FISHERIES (IRANIAN JOURNAL OF NATURAL RESOURCES)[Internet]. 2020;73(1 ):91-100. Available from: https://sid.ir/paper/161933/en

    IEEE: Copy

    HADI GHAFARI, YAZDAN MORADI, MELIKA NAZEMI, and REZA SAFARI, “Evaluation of anti-inflammatory effects of methanolic extract of Persian Gulf sea cucumber (Holothuria leucospilota) on rats (Rattus rattus),” JOURNAL OF FISHERIES (IRANIAN JOURNAL OF NATURAL RESOURCES), vol. 73, no. 1 , pp. 91–100, 2020, [Online]. Available: https://sid.ir/paper/161933/en

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