Effect of Extracted Sterols from Persian Gulf Red Algae on Human Skin Cells Collagen

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Pishehvarzad Fatemeh; HOSSEINI SEYED VALI; FARAHMAND HAMID; Lastra Mariano; Lopez Sonia

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Journal: Journal of Fisheries Year:2018 | Volume:71 | Issue:3 Page(s): 208-215

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Title

Effect of Extracted Sterols from Persian Gulf Red Algae on Human Skin Cells Collagen

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Keywords

ProcollagenQ1

CytotoxicityQ1

SterolQ1

Persian Gulf red algaeQ1

Skin healingQ1

Gracilaria salicorniaQ1

Abstract

Skin aging is accompanied by up regulation of the matrix metalloproteinase (MMP) expression and down regulation of collagen synthesis. Extracted Sterols of marine algaes have been reported as anti-cancer agents and antioxidants, which can indicate the potential for anti-wrinkle properties in the human skin. In this study, the Sterols extracted from Persian Gulf red algae Gracilaria salicornia were evaluated at concentrations 1. 7, 3. 5, 7, 14, 28, 56 and 112 μ g / ml for determination of Procollagen synthesis in human skin cells. To determine the acceptable dose of this precursor, the Cytotoxicity test of G. salicornia Sterols on the human skin fibroblast cells was tested at levels 2. 3, 4. 6, 9. 3, 18. 75, 37. 5, 75, 150 and 300 μ g/ml. The results indicate increased Procollagen synthesis in the skin cells by increasing the concentration of Sterols, and the lack of toxicity of this substance in the required dosage of the treatment. The extracts IC50 for human skin fibroblasts was 111 μ g / ml. The effect of extracts on increasing of skin Procollagen showed significant differences at concentrations 1. 75 to 112 μ g / ml (P<0. 0001). Therefore, extracted Sterols can play an important role on reducing the skin aging process due to the synthesis of skin cells Procollagen. More research is needed for other uses of algae Sterols for the use of cosmetic products.

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APA: Copy

Pishehvarzad, Fatemeh, HOSSEINI, SEYED VALI, FARAHMAND, HAMID, Lastra, Mariano, & Lopez, Sonia. (2018). Effect of Extracted Sterols from Persian Gulf Red Algae on Human Skin Cells Collagen. JOURNAL OF FISHERIES (IRANIAN JOURNAL OF NATURAL RESOURCES), 71(3 ), 208-215. SID. https://sid.ir/paper/162110/en

Vancouver: Copy

Pishehvarzad Fatemeh, HOSSEINI SEYED VALI, FARAHMAND HAMID, Lastra Mariano, Lopez Sonia. Effect of Extracted Sterols from Persian Gulf Red Algae on Human Skin Cells Collagen. JOURNAL OF FISHERIES (IRANIAN JOURNAL OF NATURAL RESOURCES)[Internet]. 2018;71(3 ):208-215. Available from: https://sid.ir/paper/162110/en

IEEE: Copy

Fatemeh Pishehvarzad, SEYED VALI HOSSEINI, HAMID FARAHMAND, Mariano Lastra, and Sonia Lopez, “Effect of Extracted Sterols from Persian Gulf Red Algae on Human Skin Cells Collagen,” JOURNAL OF FISHERIES (IRANIAN JOURNAL OF NATURAL RESOURCES), vol. 71, no. 3 , pp. 208–215, 2018, [Online]. Available: https://sid.ir/paper/162110/en

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