مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Genetic Characterization of Infectious Bursal Disease Virus Vaccines in Iran: Helping to make the right decision in choosing the right vaccine and mo-lecular epidemiology studies

Pages

  32-45

Abstract

 Infectious bursal disease virus (IBDV) or Gumboro causes an acute and highly contagious infectious disease characterized by a severe suppression of the immune system (especially humoral) of chickens. This virus is a highly resistant RNA virus of the Birnaviridae family, whose genetic diversity has significant implications for disease manifestations, diagnosis and control. The new genetic classification of this virus is based on the nucleotide sequence of the A (VP2) and B (VP1) parts of its genome. Due to some problems and restrictions in importing Vaccines from European countries, the Iranian veterinary organization has agreed in recent years to import Gumboro Vaccine and produce it locally. The aim of this study is to investigate the phylogenetic and classification of Vaccine strains and their compatibility with circulating viruses. In this study, four types of live attenuated Vaccines (IBD07IR, Razi Vaccine and Serology Institute, Iran), B87 (QYH, China), GUMBOHATCH immunocomplex (Hypera, Spain) and MyHatch UPM 93 Vaccine (MVP, Malaysia) were evaluated and then the genes encoding for two proteins VP2 and VP1 were amplified by RT-PCR method and sequenced. In brief, the live attenuated Vaccines IBD07IR and B87 (Intermediate) and the Gumbohatch Vaccine (Intermediate Plus) were categorized as group A1B1 and the MyHatch UPM 93 Vaccine (Intermediate Plus) was classified as group A3B2. The results of this study can provide researchers and clinicians with appropriate information in the field of Gumboro Vaccines and Vaccine selection and can be used in molecular epidemiologic studies in Iran.

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