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Title

ASSESSMENT OF THE EFFECT OF CO- ADMINISTRATION OF ALOE VERA GEL AND FENUGREEK SEED HYDROETHANOLIC EXTRACT ON THE IMPROVEMENT OF FULL-THICKNESS EXCISIONAL SKIN WOUND HEALING IN DIABETIC MICE

Pages

  285-295

Abstract

 Delayed wound healing is one of the complications of DIABETES. Therefore, attempts in finding effective agents to promote the wound healing process is clinically important. The present study was performed to investigate the effects of ALOE VERA GEL and HYDROETHANOLIC EXTRACT of FENUGREEK SEED on wound healing process in 54 MICE suffering from type 2 DIABETES. A single full-thickness excisional wound was created on the back of each MICE with 6-mm punch biopsy. The animal were divided to three groups consisting of control group, 5% ALOE VERA GEL treatment group and combination 5% ALOE VERA GEL + 5% FENUGREEK SEED HYDROETHANOLIC EXTRACT treatment group. The rate of wound closure was then measured daily for 15 days. The rate of wound healing, tissue edema, cellular infiltration, neo-vascularization and collagen deposition between groups were evaluated microscopically. Significant increase was shown (p<0.05) in the wound contraction rate in both treatment groups compared to the control group. The edema score decreased in both treatment groups compared to the control group, whereas the new vessel formation, fibroblast distribution and collagen production was increased particularly in combination treatment group. These results indicated that topical administration of 5% ALOE VERA GEL + 5% FENUGREEK SEED HYDROETHANOLIC EXTRACT accelerated full-thickness excisional wound healing in type 2 diabetic MICE.

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    APA: Copy

    FARAHPOUR, M.R., & AGHAEI, M.. (2016). ASSESSMENT OF THE EFFECT OF CO- ADMINISTRATION OF ALOE VERA GEL AND FENUGREEK SEED HYDROETHANOLIC EXTRACT ON THE IMPROVEMENT OF FULL-THICKNESS EXCISIONAL SKIN WOUND HEALING IN DIABETIC MICE. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 9(4 (36)), 285-295. SID. https://sid.ir/paper/183080/en

    Vancouver: Copy

    FARAHPOUR M.R., AGHAEI M.. ASSESSMENT OF THE EFFECT OF CO- ADMINISTRATION OF ALOE VERA GEL AND FENUGREEK SEED HYDROETHANOLIC EXTRACT ON THE IMPROVEMENT OF FULL-THICKNESS EXCISIONAL SKIN WOUND HEALING IN DIABETIC MICE. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)[Internet]. 2016;9(4 (36)):285-295. Available from: https://sid.ir/paper/183080/en

    IEEE: Copy

    M.R. FARAHPOUR, and M. AGHAEI, “ASSESSMENT OF THE EFFECT OF CO- ADMINISTRATION OF ALOE VERA GEL AND FENUGREEK SEED HYDROETHANOLIC EXTRACT ON THE IMPROVEMENT OF FULL-THICKNESS EXCISIONAL SKIN WOUND HEALING IN DIABETIC MICE,” VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), vol. 9, no. 4 (36), pp. 285–295, 2016, [Online]. Available: https://sid.ir/paper/183080/en

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