EFFECT OF CINNAMON EXTRACT ON COX-2 GENE EXPRESSION LEVEL IN LIVER AND LIPID PROFILE ALTERATIONS IN SERUM OF HEALTHY BROILER CHICKENS AND THOSE INFECTED WITH E. COLI

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TABATABAEI S.M.; BADALZADEH R.; MOHAMMADNEZHAD R.; YOUSEFI B.

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Journal: VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ) Year:2015 | Volume:9 | Issue:1 (33) Page(s): 61-72

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Title

EFFECT OF CINNAMON EXTRACT ON COX-2 GENE EXPRESSION LEVEL IN LIVER AND LIPID PROFILE ALTERATIONS IN SERUM OF HEALTHY BROILER CHICKENS AND THOSE INFECTED WITH E. COLI

Author(s)

TABATABAEI S.M. | BADALZADEH R. | MOHAMMADNEZHAD R. | YOUSEFI B. | Issue Writer Certificate

Keywords

ESCHERICHIA COLIQ1

LIPID PROFILEQ1

BROILER CHICKENSQ2

CINNAMONQ2

Abstract

The use of herbal medicine instead of antibiotics for treatment of livestock and poultry disease could have many beneficial implication due to their multiplex activities. This study has investigated the effects of CINNAMON extract on cyclooxygenase-2 (COX-2) gene expression level in liver and LIPID PROFILE alterations in serum of healthy and ESCHERICHIA COLI infested BROILER CHICKENS. Ninety Ross-308 broilers in healthy or E.coli-infected groups were received normal diet or diet supplemented with CINNAMON extract in concentrations of 100 or 200 mg/kg of diet. E. coli suspension (108cfu/ml) was injected subcutaneously after 12 days of CINNAMON administration. Seventy-two hours after E. coli injection, blood samples were taken for analysis of LIPID PROFILE alterations in serum, and then liver tissue samples were obtained for detection of COX-2 gene expression using real-time PCR. Infection with E. coli significantly decreased the levels of COX-2 gene expression as well as some variables of LIPID PROFILE including triglyceride level as compared with the control group (p<0.05). Pre-administration of CINNAMON extract in broilers diet (in both concentrations) significantly reduced the tissue levels of COX-2 gene expression and triglyceride levels in serum of BROILER CHICKENS infected with E. coli in comparison with E. coli-alone group (p<0.05). The CINNAMON extract could not induce statistically significant effects on the tested parameters in healthy broilers. Thus, pre-administration of CINNAMON extract in diets of BROILER CHICKENS may be capable of reducing the inflammatory and oxidative injuries induced by pathologic conditions such as infection with E. coli.

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APA: Copy

TABATABAEI, S.M., BADALZADEH, R., MOHAMMADNEZHAD, R., & YOUSEFI, B.. (2015). EFFECT OF CINNAMON EXTRACT ON COX-2 GENE EXPRESSION LEVEL IN LIVER AND LIPID PROFILE ALTERATIONS IN SERUM OF HEALTHY BROILER CHICKENS AND THOSE INFECTED WITH E. COLI. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 9(1 (33)), 61-72. SID. https://sid.ir/paper/183270/en

Vancouver: Copy

TABATABAEI S.M., BADALZADEH R., MOHAMMADNEZHAD R., YOUSEFI B.. EFFECT OF CINNAMON EXTRACT ON COX-2 GENE EXPRESSION LEVEL IN LIVER AND LIPID PROFILE ALTERATIONS IN SERUM OF HEALTHY BROILER CHICKENS AND THOSE INFECTED WITH E. COLI. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)[Internet]. 2015;9(1 (33)):61-72. Available from: https://sid.ir/paper/183270/en

IEEE: Copy

S.M. TABATABAEI, R. BADALZADEH, R. MOHAMMADNEZHAD, and B. YOUSEFI, “EFFECT OF CINNAMON EXTRACT ON COX-2 GENE EXPRESSION LEVEL IN LIVER AND LIPID PROFILE ALTERATIONS IN SERUM OF HEALTHY BROILER CHICKENS AND THOSE INFECTED WITH E. COLI,” VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), vol. 9, no. 1 (33), pp. 61–72, 2015, [Online]. Available: https://sid.ir/paper/183270/en

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