Tracking signatures of positive selection in Iranian Afshari and Moghani Sheep breeds using genomic data

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YOUSEFI ZOHREH; BEIGE NASIRI MOHAMMAD TAGHI; MORADI MOHAMAD HOSSEIN; ABDOLLAHI ARPANAHI ROSTAM; Shirali MASUOD

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Journal: Iranian Journal of Animal Science Year:2018 | Volume:48 | Issue:4 Page(s): 593-602

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Title

Tracking signatures of positive selection in Iranian Afshari and Moghani Sheep breeds using genomic data

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Keywords

Afshari sheepQ1

candidate genesQ1

Moghani sheepQ2

population differentiation indexQ1

selection signatureQ1

Abstract

The detection of genomic regions under positive selection is one of the important topics in population genetics. The objective of the present study was to identify the genomic regions that have been under natural or artificial selection in Afshari and Moghani sheep breeds. Seventy-five samples from Afshari (N=41) and Moghani (N=34) breeds have been genotyped using the Illumina Ovine SNP50K BeadChip. Unbiased method of population differentiation index (Theta) was used to detect the positive selection signatures using Lokern R package. The results of this study revealed 16 genetic regions on chromosomes 2, 3, 4, 8, 9, 13, 15, 22 and 26 where have been under positive selection in these two Iranian sheep breeds. A majority of the genes were involved in signal transduction pathways in a wide variety of cellular and biochemical processes. In particular, selection signatures were identified spanning several genes that directly or indirectly influenced pigmentation (EDN3, BNC2), skeletal morphology and body size (ALX4, EXT2, BMP2), metabolic regulation (PPP1R3D) and immune response (IL2RB). The results of the present study and identified genomic regions suggest that the selection during the evolution and adaptation to the different environments and geographical conditions led to population differentiation in Afshari and Moghani breeds. In conclusion, finding of this study can play an important role in tracing the genomic regions associated with the distinctive traits of these two indigenous breeds.

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APA: Copy

YOUSEFI, ZOHREH, BEIGE NASIRI, MOHAMMAD TAGHI, MORADI, MOHAMAD HOSSEIN, ABDOLLAHI ARPANAHI, ROSTAM, & Shirali, MASUOD. (2018). Tracking signatures of positive selection in Iranian Afshari and Moghani Sheep breeds using genomic data. IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES), 48(4 ), 593-602. SID. https://sid.ir/paper/193501/en

Vancouver: Copy

YOUSEFI ZOHREH, BEIGE NASIRI MOHAMMAD TAGHI, MORADI MOHAMAD HOSSEIN, ABDOLLAHI ARPANAHI ROSTAM, Shirali MASUOD. Tracking signatures of positive selection in Iranian Afshari and Moghani Sheep breeds using genomic data. IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES)[Internet]. 2018;48(4 ):593-602. Available from: https://sid.ir/paper/193501/en

IEEE: Copy

ZOHREH YOUSEFI, MOHAMMAD TAGHI BEIGE NASIRI, MOHAMAD HOSSEIN MORADI, ROSTAM ABDOLLAHI ARPANAHI, and MASUOD Shirali, “Tracking signatures of positive selection in Iranian Afshari and Moghani Sheep breeds using genomic data,” IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES), vol. 48, no. 4 , pp. 593–602, 2018, [Online]. Available: https://sid.ir/paper/193501/en

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