EVALUATION OF ANTIFUNGAL ACTIVITY OF TOPICAL ROSMARINUS EFFICINALIS ESSENTIAL OIL ON INFECTED CUTANEOUS WOUND WITH CANDIDA ALBICANS IN RATS: HISTOPATHOLOGICAL STUDY

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NEJATI H.; FARAHPOUR M.R.; NEYRIZ NAGHADEHI M.

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Paper Information

Journal: JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN Year:2014 | Volume:11 (NEW) | Issue:3 (46) Page(s): 1397-1405

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Title

EVALUATION OF ANTIFUNGAL ACTIVITY OF TOPICAL ROSMARINUS EFFICINALIS ESSENTIAL OIL ON INFECTED CUTANEOUS WOUND WITH CANDIDA ALBICANS IN RATS: HISTOPATHOLOGICAL STUDY

Author(s)

NEJATI H. | FARAHPOUR M.R. | NEYRIZ NAGHADEHI M. | Issue Writer Certificate

Keywords

CANDIDA ALBICANSQ2

ROSMARINUS OFFICINALISQ1

WOUNDQ1

HISTOPATHOLOGYQ2

RATQ2

Abstract

Today, due to side effects and development of drug resistance to Azol drugs and its derivatives, which used for treatment of Candida infections in either topical or oral forms, led to the use of biological materials. One of medicinal herb have been used more frequently, the past to the present, is Rosemary (Rosmarinus officinalis L.). In this study on 45 male Wistar-albino RATs (weight 210±10 g), after general anesthesia, and a WOUND square with dimensions 1.5 in the 1.5 cm area between the shoulder, immediately was applied to the WOUND 0.1 ml of the suspension containing 1.5´107 CFU CANDIDA ALBICANS yeast. Then tested in three groups of 15 RATs each (control, topical ointment containing 1.5% and 3% ROSMARINUS OFFICINALIS oil) were randomly distributed into 5 subgroups of 3 RATs each (sample groups on different days) groups. End of days 4th, 8th, 12th, 16th and 20th from WOUNDs of different groups, in order to HISTOPATHOLOGY and yeast counts by a special punch biopsy specimen. Investigation showed that the use of topical 1.5 and 3 percent of Rosmarinus essential oil compared with the control group cause the decreased substantially in infection RATes and increased volume production of collagen and is lined. According to the finding results, WOUND healing is better at 3% ROSMARINUS OFFICINALIS essential oil ointment treated group, compared to lower treatment dose and control groups.

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APA: Copy

NEJATI, H., FARAHPOUR, M.R., & NEYRIZ NAGHADEHI, M.. (2014). EVALUATION OF ANTIFUNGAL ACTIVITY OF TOPICAL ROSMARINUS EFFICINALIS ESSENTIAL OIL ON INFECTED CUTANEOUS WOUND WITH CANDIDA ALBICANS IN RATS: HISTOPATHOLOGICAL STUDY. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, 11 (NEW)(3 (46)), 1397-1405. SID. https://sid.ir/paper/197425/en

Vancouver: Copy

NEJATI H., FARAHPOUR M.R., NEYRIZ NAGHADEHI M.. EVALUATION OF ANTIFUNGAL ACTIVITY OF TOPICAL ROSMARINUS EFFICINALIS ESSENTIAL OIL ON INFECTED CUTANEOUS WOUND WITH CANDIDA ALBICANS IN RATS: HISTOPATHOLOGICAL STUDY. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN[Internet]. 2014;11 (NEW)(3 (46)):1397-1405. Available from: https://sid.ir/paper/197425/en

IEEE: Copy

H. NEJATI, M.R. FARAHPOUR, and M. NEYRIZ NAGHADEHI, “EVALUATION OF ANTIFUNGAL ACTIVITY OF TOPICAL ROSMARINUS EFFICINALIS ESSENTIAL OIL ON INFECTED CUTANEOUS WOUND WITH CANDIDA ALBICANS IN RATS: HISTOPATHOLOGICAL STUDY,” JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, vol. 11 (NEW), no. 3 (46), pp. 1397–1405, 2014, [Online]. Available: https://sid.ir/paper/197425/en

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