EVALUATION OF HISTOPATHOLOGICAL AND HISTOMORPHOMETERICAL CHANGES OF TESTICULAR TISSUE FOLLOWING CONSUMPTION OF BUSULFAN IN CAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ESMATPARAST M.; TAJIK P.; GHASEMZADEH NAVA H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN Year:2018 | Volume:15 (NEW) | Issue:1 (60) Page(s): 2421-2428

Download Full-Text

Persian Verion

View:

1,512

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF HISTOPATHOLOGICAL AND HISTOMORPHOMETERICAL CHANGES OF TESTICULAR TISSUE FOLLOWING CONSUMPTION OF BUSULFAN IN CAT

Author(s)

ESMATPARAST M. | TAJIK P. | GHASEMZADEH NAVA H. | Issue Writer Certificate

Keywords

BUSULFANQ1

SPERMATOGENESISQ2

CATQ2

TESTISQ2

Abstract

In order to successfully transplant spermatogonial cells need to be defined a suitable model for producing azoospermia animals. Several methods are available for made azoospermic animals, include systemic injection of BUSULFAN, radiation, cold ischemia and increased testicular temperature. The aim of the study is development of a method for producing azoospermic CATs in order to prepare them for spermatogonial stem cells transplantation. In this study, 15 domestic short hair CATs at the age of 3 to 5 month were divided in 3 groups. After first injection, at 5, 9, 13 and 17 weeks, doses of zero, four and ten mg/kg of BUSULFAN intravenously were injected to the control and treatment groups, respectively. Two months after the injections testicles surgically removed and evaluated. The mean diameter of the seminiferous tubules and germinal epithelium thickness was calculated. Sertoli and leydig cells were also evaluated. Histological evaluation of treating groups with 4 and 10 mg/kg BUSULFAN shows different degrees of degradation of seminiferous tubules. The thickness of germinal epithelium significantly decreased. BUSULFAN through its effect on germ cells and somatic cells can disrupt SPERMATOGENESIS and induced azoospermia.

Cites

No record.

References

No record.

Cite

APA: Copy

ESMATPARAST, M., TAJIK, P., & GHASEMZADEH NAVA, H.. (2018). EVALUATION OF HISTOPATHOLOGICAL AND HISTOMORPHOMETERICAL CHANGES OF TESTICULAR TISSUE FOLLOWING CONSUMPTION OF BUSULFAN IN CAT. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, 15 (NEW)(1 (60) ), 2421-2428. SID. https://sid.ir/paper/197450/en

Vancouver: Copy

ESMATPARAST M., TAJIK P., GHASEMZADEH NAVA H.. EVALUATION OF HISTOPATHOLOGICAL AND HISTOMORPHOMETERICAL CHANGES OF TESTICULAR TISSUE FOLLOWING CONSUMPTION OF BUSULFAN IN CAT. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN[Internet]. 2018;15 (NEW)(1 (60) ):2421-2428. Available from: https://sid.ir/paper/197450/en

IEEE: Copy

M. ESMATPARAST, P. TAJIK, and H. GHASEMZADEH NAVA, “EVALUATION OF HISTOPATHOLOGICAL AND HISTOMORPHOMETERICAL CHANGES OF TESTICULAR TISSUE FOLLOWING CONSUMPTION OF BUSULFAN IN CAT,” JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, vol. 15 (NEW), no. 1 (60) , pp. 2421–2428, 2018, [Online]. Available: https://sid.ir/paper/197450/en

Related Journal Papers