EXPERIMENTAL STUDY ON INHIBITORY EFFECTS OF TOMATO (SOLANUM LYCOPERSICUM) PULP ON OXIDATIVE STRESS IN DMBA-INDUCED SKIN CARCINOMA IN THE MOUSE

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MOHAJERI D.

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Journal: JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN Year:2014 | Volume:11 (NEW) | Issue:1 (44) Page(s): 1183-1194

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Title

EXPERIMENTAL STUDY ON INHIBITORY EFFECTS OF TOMATO (SOLANUM LYCOPERSICUM) PULP ON OXIDATIVE STRESS IN DMBA-INDUCED SKIN CARCINOMA IN THE MOUSE

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MOHAJERI D. | Issue Writer Certificate

Keywords

TOMATOQ2

OXIDATIVE STRESSQ2

SKIN CARCINOMAQ2

DMBAQ2

MOUSEQ2

Abstract

Skin carcinogenesis is a malignant growth of the epidermis and the most common types of skin cancer are basal cell carcinoma and squamous cell carcinoma. Cancer chemoprevention is the use of natural, synthetic or biological substances to reverse or prevent the development of cancer. TOMATO (Solanum lycopersicum L.) because of its lycopene and bioflavonoids contents has anti-carcinogenic effects. For this purpose, 50 mice were randomly divided into five equal groups including: Normal control, Carcinogen control and Solanum lycopersicum -treated Groups (Sl 10, Sl 20 and Sl 40). TOMATO treated groups and Carcinogen control mice received three topical applications of 7, 12dimethylbenz [a] anthracene (DMBA) followed by croton oil on shaven dorsal skin for 12 weeks. Normal control mice received topical skin applications of the vehicle, acetone, only. TOMATO pulp was simultaneously gavaged to three groups of mice at the doses of 10, 20 and 40 ml/kg. At the end of experiment, the activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) in liver tissue from all groups were assessed. Rats treated with DMBA showed significant decline in antioxidants, and elevated lipid peroxidation index in liver (p<0.05). TOMATO pulp treatment significantly reduced lipid peroxidation product (MDA), and brought back the liver antioxidants in a dose dependent manner (p<0/05). The results obtained showed, TOMATO inhibits DMBA-induced SKIN CARCINOMA in mice through the induction of cellular antioxidant defense systems.

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APA: Copy

MOHAJERI, D.. (2014). EXPERIMENTAL STUDY ON INHIBITORY EFFECTS OF TOMATO (SOLANUM LYCOPERSICUM) PULP ON OXIDATIVE STRESS IN DMBA-INDUCED SKIN CARCINOMA IN THE MOUSE. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, 11 (NEW)(1 (44)), 1183-1194. SID. https://sid.ir/paper/197511/en

Vancouver: Copy

MOHAJERI D.. EXPERIMENTAL STUDY ON INHIBITORY EFFECTS OF TOMATO (SOLANUM LYCOPERSICUM) PULP ON OXIDATIVE STRESS IN DMBA-INDUCED SKIN CARCINOMA IN THE MOUSE. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN[Internet]. 2014;11 (NEW)(1 (44)):1183-1194. Available from: https://sid.ir/paper/197511/en

IEEE: Copy

D. MOHAJERI, “EXPERIMENTAL STUDY ON INHIBITORY EFFECTS OF TOMATO (SOLANUM LYCOPERSICUM) PULP ON OXIDATIVE STRESS IN DMBA-INDUCED SKIN CARCINOMA IN THE MOUSE,” JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, vol. 11 (NEW), no. 1 (44), pp. 1183–1194, 2014, [Online]. Available: https://sid.ir/paper/197511/en

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