ASSES ABILITY OF MUTANT VARIETY OF RIBOSOMAL PROTEIN L3 (RPL3W258C/H259Y) IN RESISTANCE TO MYCOTOXIN OF FUSARIUM GRAMINEARUM BY USING SACCHAROMYCES CEREVISIAE

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ABKAR M.; SANJARIAN F.; MOUSAVI AMIR

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Journal: Crop Biotechnology Year:2013 | Volume:2 | Issue:3 Page(s): 13-23

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Title

ASSES ABILITY OF MUTANT VARIETY OF RIBOSOMAL PROTEIN L3 (RPL3W258C/H259Y) IN RESISTANCE TO MYCOTOXIN OF FUSARIUM GRAMINEARUM BY USING SACCHAROMYCES CEREVISIAE

Author(s)

ABKAR M. | SANJARIAN F. | MOUSAVI AMIR | Issue Writer Certificate

Keywords

DEOXYNIVALENOLQ3

FUSARIUM HEAD BLIGHTQ2

RIBOSOMAL PROTEIN L3Q2

Abstract

Fusarium head blight (FHB) is a disease that causes major economic losses in wheat and the other cereal crops production worldwide. Moreover, contamination of food with the trichothecene mycotoxin DEOXYNIVALENOL (DON) produced by Fusarium graminearum is a major health concern for humans and animals because trichothecenes are potent cytotoxins of eukaryotic cells. Trichothecene mycotoxins inhibit translation by targeting RIBOSOMAL PROTEIN L3 at the peptidyl transferase center. In this study, we modified a Tomato (Lycopersicon esculentum) cDNA encoding the ribosomal protein RPL3 so that the amino acid residue 258 was changed from tryptophan to cysteine and the amino acid residue 259 was change from histidine to tyrosine. All version of the tomato RPL3 were introduced to DON-sensitive pdr5 and ayt1 mutant strains of Saccharomyces cerevisiae. When transgenic yeast were compared for growth in presence of DON, differences in growth rate and survival were observed among the yeasts expressing the modified versions of the tomato RPL3 genes, compared to those expressing the wild-type yeast RPL3 gene. These results could create a new field in developing FHB resistance varieties of wheat through genetic manipulation.

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APA: Copy

ABKAR, M., SANJARIAN, F., & MOUSAVI, AMIR. (2013). ASSES ABILITY OF MUTANT VARIETY OF RIBOSOMAL PROTEIN L3 (RPL3W²⁵⁸C/H²⁵⁹Y) IN RESISTANCE TO MYCOTOXIN OF FUSARIUM GRAMINEARUM BY USING SACCHAROMYCES CEREVISIAE. JOURNAL OF CROP BIOTECHNOLOGY, 2(3), 13-23. SID. https://sid.ir/paper/226804/en

Vancouver: Copy

ABKAR M., SANJARIAN F., MOUSAVI AMIR. ASSES ABILITY OF MUTANT VARIETY OF RIBOSOMAL PROTEIN L3 (RPL3W²⁵⁸C/H²⁵⁹Y) IN RESISTANCE TO MYCOTOXIN OF FUSARIUM GRAMINEARUM BY USING SACCHAROMYCES CEREVISIAE. JOURNAL OF CROP BIOTECHNOLOGY[Internet]. 2013;2(3):13-23. Available from: https://sid.ir/paper/226804/en

IEEE: Copy

M. ABKAR, F. SANJARIAN, and AMIR MOUSAVI, “ASSES ABILITY OF MUTANT VARIETY OF RIBOSOMAL PROTEIN L3 (RPL3W²⁵⁸C/H²⁵⁹Y) IN RESISTANCE TO MYCOTOXIN OF FUSARIUM GRAMINEARUM BY USING SACCHAROMYCES CEREVISIAE,” JOURNAL OF CROP BIOTECHNOLOGY, vol. 2, no. 3, pp. 13–23, 2013, [Online]. Available: https://sid.ir/paper/226804/en

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