Histomorphometric and immunohistochemical evaluation of angiogenesis in ischemia by tissue engineering in rats: Role of mast cells

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Amani Saeede; SHAHROOZ RASOUL; MORTAZ ESMAEIL; HOBBENAGHI RAHIM; MOHAMMADI RAHIM; Baradar Khoshfetrat ali

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Journal: VETERINARY RESEARCH FORUM Year:2019 | Volume:10 | Issue:1 Page(s): 23-30

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Title

Histomorphometric and immunohistochemical evaluation of angiogenesis in ischemia by tissue engineering in rats: Role of mast cells

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Keywords

AngiogenesisQ1

ImmunohistochemistryQ1

Mast cellQ1

RatQ1

Tissue engineeringQ1

Abstract

The aim of this study was to find a proper method for improvement of ischemic condition in the Rat hind limb and also to observe the efficacy of cell engraftment with alginate/gelatin three-dimensional scaffolds. Eighteen male Wistar Rats weighing 200 to 250 g were randomly divided into three groups (n = 6) including a) ischemia group; in which femoral artery was removed after ligation at the distance of 5 mm, b) scaffold group; in which hydrogel scaffold was added to the site of transected femoral artery and c) test group; in which in addition to hydrogel scaffold, Mast cells (MCs) were also added (1 × 106 cells). Analysis of capillary density, artery diameter, histomorphometric parameters and Immunohistochemistry in transected location were done on day 14 after femoral artery transection. The average number of blood capillary was significantly higher in the test group than other groups. Also, the average number of medium and large blood vessels was significantly higher in the test group compared to ischemia and scaffold groups. Application of MCs through the use of hydrogel scaffolds (alginate/gelatin) can be considered as a new approach in the application of stem cells for therapeutic Angiogenesis under ischemic conditions which can improve the Angiogenesis process in patients with peripheral artery diseases.

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APA: Copy

Amani, Saeede, SHAHROOZ, RASOUL, MORTAZ, ESMAEIL, HOBBENAGHI, RAHIM, MOHAMMADI, RAHIM, & Baradar Khoshfetrat, ali. (2019). Histomorphometric and immunohistochemical evaluation of angiogenesis in ischemia by tissue engineering in rats: Role of mast cells. VETERINARY RESEARCH FORUM, 10(1 ), 23-30. SID. https://sid.ir/paper/263625/en

Vancouver: Copy

Amani Saeede, SHAHROOZ RASOUL, MORTAZ ESMAEIL, HOBBENAGHI RAHIM, MOHAMMADI RAHIM, Baradar Khoshfetrat ali. Histomorphometric and immunohistochemical evaluation of angiogenesis in ischemia by tissue engineering in rats: Role of mast cells. VETERINARY RESEARCH FORUM[Internet]. 2019;10(1 ):23-30. Available from: https://sid.ir/paper/263625/en

IEEE: Copy

Saeede Amani, RASOUL SHAHROOZ, ESMAEIL MORTAZ, RAHIM HOBBENAGHI, RAHIM MOHAMMADI, and ali Baradar Khoshfetrat, “Histomorphometric and immunohistochemical evaluation of angiogenesis in ischemia by tissue engineering in rats: Role of mast cells,” VETERINARY RESEARCH FORUM, vol. 10, no. 1 , pp. 23–30, 2019, [Online]. Available: https://sid.ir/paper/263625/en

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