Study of Toxic Effects of Oxothiazole Derivative as a New Antibacterial Agent

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Beyzaei Hamid; JAMSHIDIAN ABBAS; HAJINEZHAD MOHAMMAD REZA; HASHEMI SEYED HADI; Amel Nasim; ABDOLLAHI MALIHEH; Arab Sahebi Fatemeh; GHASEMI BEHZAD

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Journal: IRANIAN JOURNAL OF VETERINARY SCIENCE AND TECHNOLOGY Year:2018 | Volume:10 | Issue:2 Page(s): 17-21

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Title

Study of Toxic Effects of Oxothiazole Derivative as a New Antibacterial Agent

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Keywords

Toxic effects

Histopathological study

Oxothiazole derivative

Abstract

The spread of antibiotic-resistant bacteria in many humans and animals has driven researches to identify and design novel antibacterial agents. In vitro inhibitory activity of (2E)-2-(4, 5-dihydro-4-oxothiazol-2-yl)-2-(thiazolidin-2-ylidene) acetonitrile against many bacterial pathogens has been proven in both veterinary and human medicine. In this study, its in vivo Toxic effects was studied in mice. The median lethal dose (LD50) value of 239. 88 mg/kg was estimated using intraperitoneal injection in 8 groups of mice after 48 h treatment. Then, intraperitoneal injections of LD50 of oxothiazole solution into 4 other mice were done to evaluate histopathological changes in their liver and kidney tissues. The histopathological studies were identified as fatty change, hepatitis, necrosis and regeneration in liver, and fibrosis, necrosis, nephritis, hyaline cast and hyperaemia in kidney. In conclusion, the synthesized Oxothiazole derivative causes renal and hepatic toxicity in mice at medium concentrations. The change of thiazole substituents and complexation may reduce its toxicity.

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APA: Copy

Beyzaei, Hamid, JAMSHIDIAN, ABBAS, HAJINEZHAD, MOHAMMAD REZA, HASHEMI, SEYED HADI, Amel, Nasim, ABDOLLAHI, MALIHEH, Arab Sahebi, Fatemeh, & GHASEMI, BEHZAD. (2018). Study of Toxic Effects of Oxothiazole Derivative as a New Antibacterial Agent. IRANIAN JOURNAL OF VETERINARY SCIENCE AND TECHNOLOGY, 10(2 ), 17-21. SID. https://sid.ir/paper/269131/en

Vancouver: Copy

Beyzaei Hamid, JAMSHIDIAN ABBAS, HAJINEZHAD MOHAMMAD REZA, HASHEMI SEYED HADI, Amel Nasim, ABDOLLAHI MALIHEH, Arab Sahebi Fatemeh, GHASEMI BEHZAD. Study of Toxic Effects of Oxothiazole Derivative as a New Antibacterial Agent. IRANIAN JOURNAL OF VETERINARY SCIENCE AND TECHNOLOGY[Internet]. 2018;10(2 ):17-21. Available from: https://sid.ir/paper/269131/en

IEEE: Copy

Hamid Beyzaei, ABBAS JAMSHIDIAN, MOHAMMAD REZA HAJINEZHAD, SEYED HADI HASHEMI, Nasim Amel, MALIHEH ABDOLLAHI, Fatemeh Arab Sahebi, and BEHZAD GHASEMI, “Study of Toxic Effects of Oxothiazole Derivative as a New Antibacterial Agent,” IRANIAN JOURNAL OF VETERINARY SCIENCE AND TECHNOLOGY, vol. 10, no. 2 , pp. 17–21, 2018, [Online]. Available: https://sid.ir/paper/269131/en

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