STUDYON INTERFERON GAMMAGENE POLYMORPHISM IN SHAULSHEEP

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NIKBAKHT BOROUJENI GH.R.; EMAM S.M.; MAHMOUDZADEH HOMAYOUN; BARJESTEH N.

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Journal: Journal of Veterinary Research Year:2009 | Volume:64 | Issue:3 Page(s): 199-204

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Title

STUDYON INTERFERON GAMMAGENE POLYMORPHISM IN SHAULSHEEP

Author(s)

NIKBAKHT BOROUJENI GH.R. | EMAM S.M. | MAHMOUDZADEH HOMAYOUN | BARJESTEH N. | Issue Writer Certificate

Keywords

INTERFERON GAMMAQ3

SHAUL SHEEPQ3

GENE POLYMORPHISMQ2

HETERODUPLEX MOBILITY ANALYSISQ3

SINGLE STRAND CONFORMATION POLYMORPHISM ANALYSISQ3

Abstract

INTERFERON GAMMA (IFN-g) is a cytokine produced by activated T lymphocytes and natural killer cells. It plays an important role in innate and adaptive immunity. IFN-g gene is polymorphic and its haplotype has been associated with resistance to nematode infestations which are the most important parasites of domestic sheep worldwide. To evaluate IFN-g polymorphism in Iranian SHAUL SHEEP population, 136 blood samples were collected. Genomic DNA were extracted and amplified by PCR using specific primers for exon 3 of IFN-g gene. After gene amplification, SSCP and HETERODUPLEX MOBILITY ANALYSIS carried out on polyacrylamid gel. Five unique SSCP patterns were detected in this population which 3 of them represent 3 alleles. Although HETERODUPLEX MOBILITY ANALYSIS demonstrated that all samples were homozygous, SSCP could reveal heterozygosity at frequency of 40. 4% in the studied population. Data obtained from the present study have revealed that IFN-g gene was a highly polymorphic in Iranian Shaul ecotype. This will be useful to study host-pathogen interaction and to evaluate association between resistance or susceptibility to disease with IFN-g in this ecotype.

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APA: Copy

NIKBAKHT BOROUJENI, GH.R., EMAM, S.M., MAHMOUDZADEH, HOMAYOUN, & BARJESTEH, N.. (2009). STUDYON INTERFERON GAMMAGENE POLYMORPHISM IN SHAULSHEEP. JOURNAL OF VETERINARY RESEARCH, 64(3), 199-204. SID. https://sid.ir/paper/34933/en

Vancouver: Copy

NIKBAKHT BOROUJENI GH.R., EMAM S.M., MAHMOUDZADEH HOMAYOUN, BARJESTEH N.. STUDYON INTERFERON GAMMAGENE POLYMORPHISM IN SHAULSHEEP. JOURNAL OF VETERINARY RESEARCH[Internet]. 2009;64(3):199-204. Available from: https://sid.ir/paper/34933/en

IEEE: Copy

GH.R. NIKBAKHT BOROUJENI, S.M. EMAM, HOMAYOUN MAHMOUDZADEH, and N. BARJESTEH, “STUDYON INTERFERON GAMMAGENE POLYMORPHISM IN SHAULSHEEP,” JOURNAL OF VETERINARY RESEARCH, vol. 64, no. 3, pp. 199–204, 2009, [Online]. Available: https://sid.ir/paper/34933/en

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