GFAP and S100 expression following treatment with Oat Extract in Experimental Sciatic Nerve Injury in Rats

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darzian rostami zahra; ASGHARI AHMAD; Jahandideh Alireza; MORTAZAVI PEJMAN; AKBARZADEH ABOLFAZL

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Journal: JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN Year:2020 | Volume:16 | Issue:4 (67) Page(s): 2949-2956

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Title

GFAP and S100 expression following treatment with Oat Extract in Experimental Sciatic Nerve Injury in Rats

Author(s)

Keywords

Oat extractQ1

Sciatic nerve injuryQ1

Rat‚Q1

GFAP‚Q2

S100 Q2

Abstract

Based on previous studies, Oat plant is a medicinal herb with antioxidant and anti-inflammatory properties. But no studies have been done on the role of this plant in restoring the sciatic nerve. The aim of this study was to determine the expression of GFAP and S100 after treatment with Oat extracts in the experimental Sciatic nerve injury in rat. Fifty adult male rats were divided into five groups (n=10). Group 1 kept as sham‚ group 2: control group (nerve injury without treatment). In groups 3-5 Sciatic nerve injury was done, then animal received oral gavage of the Oat extract (100, 200 and 400 mg/kg), respectively. Then 2 and 4 weeks later, rats were Euthanasia or death by pity for Immunohistochemistry (IHC) evaluation of nerve repair. The analysis of immunohistochemical results and the expression of S100 and GFAP after 2 weeks period showed that in the 4-5 group with therapeutic dose (200-400 mg / kg), the expression of the gene was significantly reduced compared to the control group (P <0. 05). Also, the results of gene expression after 4 weeks showed that group 5 with a dose (400 mg / kg) had significantly decreased compared to the control group (P <0. 05). These results suggested Oat extract has positive effect with (P <0. 05) on sciatic nerve repair in rat.

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APA: Copy

darzian rostami, zahra, ASGHARI, AHMAD, Jahandideh, Alireza, MORTAZAVI, PEJMAN, & AKBARZADEH, ABOLFAZL. (2020). GFAP and S100 expression following treatment with Oat Extract in Experimental Sciatic Nerve Injury in Rats. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, 16(4 (67) ), 2949-2956. SID. https://sid.ir/paper/359590/en

Vancouver: Copy

darzian rostami zahra, ASGHARI AHMAD, Jahandideh Alireza, MORTAZAVI PEJMAN, AKBARZADEH ABOLFAZL. GFAP and S100 expression following treatment with Oat Extract in Experimental Sciatic Nerve Injury in Rats. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN[Internet]. 2020;16(4 (67) ):2949-2956. Available from: https://sid.ir/paper/359590/en

IEEE: Copy

zahra darzian rostami, AHMAD ASGHARI, Alireza Jahandideh, PEJMAN MORTAZAVI, and ABOLFAZL AKBARZADEH, “GFAP and S100 expression following treatment with Oat Extract in Experimental Sciatic Nerve Injury in Rats,” JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, vol. 16, no. 4 (67) , pp. 2949–2956, 2020, [Online]. Available: https://sid.ir/paper/359590/en

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