Effects of Hesperidin During Pregnancy on Antidepressant-like behaviour in Postpartum Mice

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Khodadadeh Ava; HASSANPOUR SHAHIN; AKBARI GHASEM

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ISSN: 2588-4824

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Journal: Iranian Journal of Veterinary Medicine Year:2020 | Volume:14 | Issue:3 Page(s): 261-272

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Title

Effects of Hesperidin During Pregnancy on Antidepressant-like behaviour in Postpartum Mice

Author(s)

Khodadadeh Ava | HASSANPOUR SHAHIN | AKBARI GHASEM | Issue Writer Certificate

Keywords

PregnancyQ1

HesperidinQ1

AntidepressantQ1

AntioxidantQ1

PostpartumQ1

MiceQ2

Abstract

BACKGROUND: Post-partum depression is the most prevalent form of mental illness and herbal therapies are potential alternatives and adjuncts for its treatment. Hesperidin is the major flavonoid isolated from citrus fruits which has neuroprotective, Antioxidant and Antidepressant activity. OBJECTIVES: We studied the effect of exposure to Hesperidin during Pregnancy on Postpartum Antidepressant-like effects in Mice. METHODS: Twelve male and 40 female Mice (28-30 gr) were randomly selected and after determination of the Pregnancy using vaginal plaque, allocated into 4 experimental groups. Group 1 was kept as control and groups 2-4 were i. p. injected with 0. 1, 0. 5 and 1 mg/kg of Hesperidin on days of 5, 8, 11, 14 and 17 of Pregnancy. The control group received i. p. injection of the saline on the same days. Following Postpartum, forced swimming test (FST), tail suspension test (TST) and open field tests were used to evaluate depressive-like Antidepressant activity of Hesperidin. At the end of the study, serum Malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD) and total Antioxidant capacity (TAC) were determined. RESULTS: According to the results, administration of the different levels of the Hesperidin (0. 5 and 1 mg/ kg) at GD 5, 8, 11, 14 and 17 significantly decreased immobility time (S) in TST and FST on Postpartum Mice compared to control group (P≤ 0. 05). Pre-partum administration of Hesperidin (0. 1, 0. 5 and 1 mg/kg) had no significant effect on OFT of control group (P>0. 05). Administration of the Hesperidin (0. 5 and 1 mg/ kg) during the GD significantly decreased MDA levels on Postpartum compared to control group (P≤ 0. 05). Also, pre-partum administration of the Hesperidin (0. 1, 0. 5 and 1 mg/kg) significantly increased SOD and GPx levels on Postpartum Mice compared to control group (P≤ 0. 05). CONCLUSIONS: These results suggested pre-partum administration of Hesperidin has Antidepressant and Antioxidant effect in Postpartum Mice.

Cites

Anti-depressant effect of hesperidin in ovariectomized mice: possible involvement of dopaminergic and serotoninergic systems

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APA: Copy

Khodadadeh, Ava, HASSANPOUR, SHAHIN, & AKBARI, GHASEM. (2020). Effects of Hesperidin During Pregnancy on Antidepressant-like behaviour in Postpartum Mice. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), 14(3 ), 261-272. SID. https://sid.ir/paper/372544/en

Vancouver: Copy

Khodadadeh Ava, HASSANPOUR SHAHIN, AKBARI GHASEM. Effects of Hesperidin During Pregnancy on Antidepressant-like behaviour in Postpartum Mice. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH)[Internet]. 2020;14(3 ):261-272. Available from: https://sid.ir/paper/372544/en

IEEE: Copy

Ava Khodadadeh, SHAHIN HASSANPOUR, and GHASEM AKBARI, “Effects of Hesperidin During Pregnancy on Antidepressant-like behaviour in Postpartum Mice,” IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), vol. 14, no. 3 , pp. 261–272, 2020, [Online]. Available: https://sid.ir/paper/372544/en

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