Amelioration of Lipid Peroxidation and Antioxidant Enzymes Status in the Serum and Erythrocytes of Phenylhydrazine-Induced Anemic Male Rats: The Protective Role of Artichoke Extract (Cynara scolymus L. )

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Allahmoradi Milad; Alimohammadi Samad; CHERAGHI HADI

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Journal: Iranian Journal of Veterinary Medicine Year:2020 | Volume:14 | Issue:3 Page(s): 315-328

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Title

Amelioration of Lipid Peroxidation and Antioxidant Enzymes Status in the Serum and Erythrocytes of Phenylhydrazine-Induced Anemic Male Rats: The Protective Role of Artichoke Extract (Cynara scolymus L. )

Author(s)

Allahmoradi Milad | Alimohammadi Samad | CHERAGHI HADI | Issue Writer Certificate

Keywords

Cynara scolymusQ1

Hemolytic AnemiaQ1

Oxidative StressQ2

PhenylhydrazineQ1

RatQ1

Abstract

BACKGROUND: Hemolytic Anemia is a disorder characterized by the premature erythrocytes destruction. Phenylhydrazine (PHZ) induces Oxidative Stress and reactive oxygen species (ROS) formation, which causes Hemolytic Anemia. Cynara scolymus due to its antioxidant compounds, has been used for various therapeutic purposes in traditional medicine. OBJECTIVES: The present study was designed to evaluate the effects of Cynara scolymus extract on PHZ-induced anemia in male Rats. METHODS: Hemolytic Anemia was induced by intraperitoneal injection of PHZ (40 mg/kg) for 2 days. Thirty male Wistar Rats were divided into five groups. Group 1 (normal control). Group 2 (anemic control) received only PHZ. The groups 3 to 5 were injected with 100, 200, 400 mg/kg of the Cynara scolymus by gavage, respectively, daily from day 2 to day 15 after PHZ administRation. At the end of the treatment period, blood samples were collected to assess hematological parameters, malondialdehyde (MDA) level and antioxidant enzymes activity, including superoxide dismutase (SOD) and total antioxidant capacity (TAC) in the serum and erythrocytes. RESULTS: In anemic Rats, serum and erythrocytes MDA level increased, but SOD and TAC activity decreased significantly when compared with control group (P≤ 0. 05). These changes were amelioRated by treatment with Cynara scolymus at different doses (P≤ 0. 05). Also, improvement in several hematological parameters was observed in anemic Rats after administRation of Cynara scolymus (P≤ 0. 05). CONCLUSIONS: Cynara scolymus extract exhibits protective property against PHZ-induced Oxidative Stress presumably due to antioxidative activity.

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APA: Copy

Allahmoradi, Milad, Alimohammadi, Samad, & CHERAGHI, HADI. (2020). Amelioration of Lipid Peroxidation and Antioxidant Enzymes Status in the Serum and Erythrocytes of Phenylhydrazine-Induced Anemic Male Rats: The Protective Role of Artichoke Extract (Cynara scolymus L. ). IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), 14(3 ), 315-328. SID. https://sid.ir/paper/375399/en

Vancouver: Copy

Allahmoradi Milad, Alimohammadi Samad, CHERAGHI HADI. Amelioration of Lipid Peroxidation and Antioxidant Enzymes Status in the Serum and Erythrocytes of Phenylhydrazine-Induced Anemic Male Rats: The Protective Role of Artichoke Extract (Cynara scolymus L. ). IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH)[Internet]. 2020;14(3 ):315-328. Available from: https://sid.ir/paper/375399/en

IEEE: Copy

Milad Allahmoradi, Samad Alimohammadi, and HADI CHERAGHI, “Amelioration of Lipid Peroxidation and Antioxidant Enzymes Status in the Serum and Erythrocytes of Phenylhydrazine-Induced Anemic Male Rats: The Protective Role of Artichoke Extract (Cynara scolymus L. ),” IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), vol. 14, no. 3 , pp. 315–328, 2020, [Online]. Available: https://sid.ir/paper/375399/en

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