Minced Calf Lung Surfactant Extract Peripheral Blood Mononuclear Cells to Release IFN-γ and TGF-β : A Regulation Response for Lung

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EFTEKHARI ZOHREH; Mokhber Dezfouli Mohammd Reza; Beikzadeh Babak

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Journal: Iranian Journal of Veterinary Medicine Year:2019 | Volume:13 | Issue:4 Page(s): 343-353

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Title

Minced Calf Lung Surfactant Extract Peripheral Blood Mononuclear Cells to Release IFN-γ and TGF-β : A Regulation Response for Lung

Author(s)

EFTEKHARI ZOHREH | Mokhber Dezfouli Mohammd Reza | Beikzadeh Babak | Issue Writer Certificate

Keywords

Calf lung surfactants extractQ1

cytokines levelQ1

exogenous lung surfactantQ1

regulatory responseQ1

Abstract

BACKGROUND: Inflammatory reactions in pathophysiologic conditions of lung are a critical problem in the treatment process, which in some cases lead to death, particularly in neonate. exogenous lung surfactant has been considered as a candidate to treatment of inflammation in the lungs. OBJECTIVES: The aim of this study is to examine the efficacy of this substance in vivo and in vitro. METHODS: Calf lung surfactant extract (CLSE) was obtained from freshly slaughtered calves’ minced isolates. For in vivo study: the New Zealand white rabbits as appropriate animal model were treated with formulated CLSE, then peripheral blood mononuclear cells (PBMC) were collected and the level and gene expression of IL-10, IL-6, IL-1β , IFN-γ and TGF-β were assessed before and after surfactant treatment for 30 days. In vitro study: four different formulated drug concentrations were added to rabbit PBMC and cytokines level and gene expression were evaluated. RESULTS: Our results indicate that IFN-γ and TGF-β increased at 24, 48 and 72 h which were statistically significant compared to baseline. While, IL-6 and IL-1β also started to decrease, IFN-γ and TGF-β increased due to surfactant therapy which reached its maximum expression after 7 days. CONCLUSIONS: This study suggested that CLSE could contribute in reducing pathology effects of pro-inflammatory cytokines by inducing regulatory response in lung which can be used as auxiliary and protective drug in respiratory diseases.

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APA: Copy

EFTEKHARI, ZOHREH, Mokhber Dezfouli, Mohammd Reza, & Beikzadeh, Babak. (2019). Minced Calf Lung Surfactant Extract Peripheral Blood Mononuclear Cells to Release IFN-γ and TGF-β : A Regulation Response for Lung. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), 13(4 ), 343-353. SID. https://sid.ir/paper/390747/en

Vancouver: Copy

EFTEKHARI ZOHREH, Mokhber Dezfouli Mohammd Reza, Beikzadeh Babak. Minced Calf Lung Surfactant Extract Peripheral Blood Mononuclear Cells to Release IFN-γ and TGF-β : A Regulation Response for Lung. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH)[Internet]. 2019;13(4 ):343-353. Available from: https://sid.ir/paper/390747/en

IEEE: Copy

ZOHREH EFTEKHARI, Mohammd Reza Mokhber Dezfouli, and Babak Beikzadeh, “Minced Calf Lung Surfactant Extract Peripheral Blood Mononuclear Cells to Release IFN-γ and TGF-β : A Regulation Response for Lung,” IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), vol. 13, no. 4 , pp. 343–353, 2019, [Online]. Available: https://sid.ir/paper/390747/en

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