Comparative Pharmacokinetics of Enrofloxacin After Subcutaneous Administration of a Novel in situ Gel Forming Preparation and a Conventional Product to Rabbits

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Rassouli Ali; Khanamani Falahatipour Sakineh; HOSSEINZADEH ARDAKANI YALDA; AKBARI JAVAR HAMID; KIANI KATAYOUN

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Journal: Iranian Journal of Veterinary Medicine Year:2021 | Volume:15 | Issue:1 Page(s): 68-78

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Title

Comparative Pharmacokinetics of Enrofloxacin After Subcutaneous Administration of a Novel in situ Gel Forming Preparation and a Conventional Product to Rabbits

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Keywords

EnrofloxacinQ1

In situ gel formingQ1

PharmacokineticsQ1

RabbitQ1

Sustained releaseQ1

Abstract

BACKGROUND: Frequent drug dosing and animal handling are usually required in conventional antimicrobial therapy but Sustained release formulations can improve compliance. OBJECTIVES: This study aimed to evaluate the pharmacokinetic (PK) parameters of a novel Sustained release enroflox-acin (ENR) hydrogel in comparison to a conventional ENR formulation in Rabbit animal model. METHODS: A total of 20 Rabbits were randomly divided into three groups and received a single dose of ENR or blank by subcutaneous (SC) injection as following: Group 1 (n=8) received ENR (10 mg/kg) using a conventional product (Enrovet® ); Group 2 (n=8) received ENR (33. 3 mg/kg) using a hydrogel formulation; and Group 3 or control group (n=4) received equal volumes of a blank hydrogel formulation. Blood samples were collected at different time points post-dosing. ENR concen-trations in plasma were estimated by high-performance liquid chromatographic (HPLC) method and PK parameters were calculated using a non-compartmental analysis. RESULTS: The ENR hydrogel released the drug in a sustained manner with mean residence time (MRT) of 78. 4 ± 15. 3 h, which was significantly more than that of the conventional formulation (7. 39 ± 2. 37 h, P<0. 05). However, maximal plasma concentration (Cmax) for ENR hydrogel (1. 41 ± 0. 76 μ g/mL) was significantly less than that of the conventional product (2. 86 ± 0. 79 μ g/mL). The relative bioavailability (Frel) was not significantly different between the two formula-tions. CONCLUSIONS: The hydrogel formulation significantly increased the MRT of ENR. Hence, it could be a promising delivery system to prolong the pharmacological activity of ENR in animals and enhance compliance.

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APA: Copy

Rassouli, Ali, Khanamani Falahatipour, Sakineh, HOSSEINZADEH ARDAKANI, YALDA, AKBARI JAVAR, HAMID, & KIANI, KATAYOUN. (2021). Comparative Pharmacokinetics of Enrofloxacin After Subcutaneous Administration of a Novel in situ Gel Forming Preparation and a Conventional Product to Rabbits. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), 15(1 ), 68-78. SID. https://sid.ir/paper/405440/en

Vancouver: Copy

Rassouli Ali, Khanamani Falahatipour Sakineh, HOSSEINZADEH ARDAKANI YALDA, AKBARI JAVAR HAMID, KIANI KATAYOUN. Comparative Pharmacokinetics of Enrofloxacin After Subcutaneous Administration of a Novel in situ Gel Forming Preparation and a Conventional Product to Rabbits. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH)[Internet]. 2021;15(1 ):68-78. Available from: https://sid.ir/paper/405440/en

IEEE: Copy

Ali Rassouli, Sakineh Khanamani Falahatipour, YALDA HOSSEINZADEH ARDAKANI, HAMID AKBARI JAVAR, and KATAYOUN KIANI, “Comparative Pharmacokinetics of Enrofloxacin After Subcutaneous Administration of a Novel in situ Gel Forming Preparation and a Conventional Product to Rabbits,” IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), vol. 15, no. 1 , pp. 68–78, 2021, [Online]. Available: https://sid.ir/paper/405440/en

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