USE OF MYCOBACTERIUM VACCAE (SRL172) AS AN IMMUNOMODULATING AGENT IN ASSOCIATION WITH MURINE MELANOMA MODEL B16-F10

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BABAN B.; SOUBERBIELLE B.; SHARAFI J.; MOHAGHEGH HAZRATI S.; SAFARAN M.

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Journal Paper

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Journal: ARCHIVES OF RAZI INSTITUTE Year:2000 | Volume:- | Issue:51 Page(s): 47-52

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Title

USE OF MYCOBACTERIUM VACCAE (SRL172) AS AN IMMUNOMODULATING AGENT IN ASSOCIATION WITH MURINE MELANOMA MODEL B16-F10

Author(s)

Keywords

MELANOMA CELL

IMMUNOMODULATING AGENT

MYCOBACTERIUM VACCAE

VACCINE

Abstract

Because of immunotherapeutic effects of MYCOBACTERIUM VACCAE (M. vaccae) by inducing Th1 responses, we tried a heat-killed suspension of M. vaccae in mice models (C57BL/6J), which had already been challenged by tumor cell lines B16-F10. The Immunization consisted of subcutaneous injection of irradiated B16-F10 cells, as an antigen, plus M. vaccae into the tail base at two inguinal sites of mice, which were injected by live wild type B16-F10 cells. Survival and tumor growth was recorded every three days for a period of three months. Increase in survival was observed whilst decrease in tumor growth was recorded. The result indicates that the heat-killed suspension of the bacterium is a powerful immunological adjuvant.

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APA: Copy

BABAN, B., SOUBERBIELLE, B., SHARAFI, J., MOHAGHEGH HAZRATI, S., & SAFARAN, M.. (2000). USE OF MYCOBACTERIUM VACCAE (SRL172) AS AN IMMUNOMODULATING AGENT IN ASSOCIATION WITH MURINE MELANOMA MODEL B16-F10. ARCHIVES OF RAZI INSTITUTE, -(51), 47-52. SID. https://sid.ir/paper/529133/en

Vancouver: Copy

BABAN B., SOUBERBIELLE B., SHARAFI J., MOHAGHEGH HAZRATI S., SAFARAN M.. USE OF MYCOBACTERIUM VACCAE (SRL172) AS AN IMMUNOMODULATING AGENT IN ASSOCIATION WITH MURINE MELANOMA MODEL B16-F10. ARCHIVES OF RAZI INSTITUTE[Internet]. 2000;-(51):47-52. Available from: https://sid.ir/paper/529133/en

IEEE: Copy

B. BABAN, B. SOUBERBIELLE, J. SHARAFI, S. MOHAGHEGH HAZRATI, and M. SAFARAN, “USE OF MYCOBACTERIUM VACCAE (SRL172) AS AN IMMUNOMODULATING AGENT IN ASSOCIATION WITH MURINE MELANOMA MODEL B16-F10,” ARCHIVES OF RAZI INSTITUTE, vol. -, no. 51, pp. 47–52, 2000, [Online]. Available: https://sid.ir/paper/529133/en

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