ACUTE AND CHRONIC EFFECTS OF AQUEOUS FERULA PERSICA EXTRACT ON BLOOD PRESSURE OF NORMOTENSIVE RATS

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GHANBARI MAHBOBEH; ZAHEDI KHORASANI MEHDI; VAKILI ABEDIN; TAHERIAN ABAS ALI; SAMENI HAMID REZA

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Journal: Rostaniha Year:2012 | Volume:14 | Issue:1 (45) Page(s): 104-108

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Title

ACUTE AND CHRONIC EFFECTS OF AQUEOUS FERULA PERSICA EXTRACT ON BLOOD PRESSURE OF NORMOTENSIVE RATS

Author(s)

Keywords

FERULA PERSICA

BLOOD PRESSURE

RAT

Abstract

Introduction: FERULA PERSICA (F. persica) have been used as lowering BLOOD PRESSURE (BP) in traditional medicine, but its therapeutic effects are not yet known in new medicine. So, in this study, the acute and chronic effects of F. persica aqueous extract were investigated on normal BP of RATs.Materials and Methods: In this experimental study, 40 male wistar RATs (250-300gr) were randomly divided to four acute groups (n=7). Femoral artery and vein was catheterized for BP recording and extract or vehicle injected in pentobarbital sodium anesthetized RATs. To evaluate chronic extract of F. persica effects on BP, the F. persica extract (30 mg/kg/day) or vehicle was orally administrated in two groups (n=6) for a month. Systolic BP was recorded non-invasively from the tail at the beginning and the end of the experiment.Results: Intravenous administration of aqueous F. persica extract with 15, 30 or 60 mg/kg dosage significantly reduced mean arterial BP of anesthetized RATs by 32%, 42% and 55% respectively (p<0.001). Chronic oral administration of extract or vehicle for a month had no effect on systolic BP of conscious RATs. Also there is no significant difference in heart RATe in different experimental groups.Conclusion: The results of this study showed that intravenous injection of aqueous F. persica extract reduces BP. So, plant component identification and it can be used for hypertensive patients.

Cites

PHYTOCHEMICAL STUDY OF METHANOLIC EXTRACT OF FERULA PERSICA WILLD. INFLORESCENCE AND ITS ANTINOCICEPTIVE EFFECT IN MALE MICE

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APA: Copy

GHANBARI, MAHBOBEH, ZAHEDI KHORASANI, MEHDI, VAKILI, ABEDIN, TAHERIAN, ABAS ALI, & SAMENI, HAMID REZA. (2012). ACUTE AND CHRONIC EFFECTS OF AQUEOUS FERULA PERSICA EXTRACT ON BLOOD PRESSURE OF NORMOTENSIVE RATS. ROSTANIHA, 14(1 (45)), 104-108. SID. https://sid.ir/paper/581297/en

Vancouver: Copy

GHANBARI MAHBOBEH, ZAHEDI KHORASANI MEHDI, VAKILI ABEDIN, TAHERIAN ABAS ALI, SAMENI HAMID REZA. ACUTE AND CHRONIC EFFECTS OF AQUEOUS FERULA PERSICA EXTRACT ON BLOOD PRESSURE OF NORMOTENSIVE RATS. ROSTANIHA[Internet]. 2012;14(1 (45)):104-108. Available from: https://sid.ir/paper/581297/en

IEEE: Copy

MAHBOBEH GHANBARI, MEHDI ZAHEDI KHORASANI, ABEDIN VAKILI, ABAS ALI TAHERIAN, and HAMID REZA SAMENI, “ACUTE AND CHRONIC EFFECTS OF AQUEOUS FERULA PERSICA EXTRACT ON BLOOD PRESSURE OF NORMOTENSIVE RATS,” ROSTANIHA, vol. 14, no. 1 (45), pp. 104–108, 2012, [Online]. Available: https://sid.ir/paper/581297/en

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