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Title

COMPARISON OF THE ANTIOXIDANT EFFECT OF VITAMIN E AND CURCUMA LONGA L. EXTRACT ON THE HISTOPATHOLOGICAL LESIONS OF LIVER AND KIDNEY FOLLOWING ASPARTAME CONSUMPTION IN RAT

Pages

  2531-2540

Abstract

 Aspartame is one of the most widely used artificial sweeteners in worldwide. The aim of this study was comparison of the ANTIOXIDANT effect of VITAMIN E and Curcuma LongaL. extract on the histopathological lesions of ASPARTAME consumption in rat.32 males adult Wistar rats were randomly divided into four equal groups as follows: (1) control, (2) receiving ASPARTAME (350 mg/kg) orally, (3) receiving ASPARTAME (350 mg/kg) orally and VITAMIN E (400 mg/kg) by peritoneal injection, (4) receiving ASPARTAME (350 mg/kg) and Curcuma Longa L. extract (200 mg/kg) orally for 1 month. At the end of the experiment, after tissue processing of LIVERs and KIDNEYs of rats, histopathological changes were examined and analyzed by using the Kruskal-Wallis test. Histopathological examination of LIVER in group 2 showed disruption of the hepatic cords, vacuolar degeneration and accumulation of necrotic materials in hepatocytes. Furthermore, renal tissue evaluation revealed degeneration of proximal and distal convoluted tubules; glomerular atrophy and increasing of urinary space. Above-mentioned lesions were significantly improved in groups 3 and 4 in comparison to group 2 (P<0.001). Besides, VITAMIN E and Curcuma Longa L. extract had higher therapeutic effects in the LIVER tissue in comparison to the KIDNEY. Furthermore, treatment with VITAMIN E caused a significant decrease of histopathological lesions in comparison to Curcuma Longa L. extract (P<0.001). These results showed the ANTIOXIDANT effects of VITAMIN E and Curcuma Longa L. extract on the lesions of ASPARTAME consumption and this protection effect was more pronounced in the group received VITAMIN E.

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    APA: Copy

    GHAVIDEL, S., DAVARI, S.A., & RASEKH, M.. (2018). COMPARISON OF THE ANTIOXIDANT EFFECT OF VITAMIN E AND CURCUMA LONGA L. EXTRACT ON THE HISTOPATHOLOGICAL LESIONS OF LIVER AND KIDNEY FOLLOWING ASPARTAME CONSUMPTION IN RAT. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, 15 (NEW)(2 (61) ), 2531-2540. SID. https://sid.ir/paper/714414/en

    Vancouver: Copy

    GHAVIDEL S., DAVARI S.A., RASEKH M.. COMPARISON OF THE ANTIOXIDANT EFFECT OF VITAMIN E AND CURCUMA LONGA L. EXTRACT ON THE HISTOPATHOLOGICAL LESIONS OF LIVER AND KIDNEY FOLLOWING ASPARTAME CONSUMPTION IN RAT. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN[Internet]. 2018;15 (NEW)(2 (61) ):2531-2540. Available from: https://sid.ir/paper/714414/en

    IEEE: Copy

    S. GHAVIDEL, S.A. DAVARI, and M. RASEKH, “COMPARISON OF THE ANTIOXIDANT EFFECT OF VITAMIN E AND CURCUMA LONGA L. EXTRACT ON THE HISTOPATHOLOGICAL LESIONS OF LIVER AND KIDNEY FOLLOWING ASPARTAME CONSUMPTION IN RAT,” JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, vol. 15 (NEW), no. 2 (61) , pp. 2531–2540, 2018, [Online]. Available: https://sid.ir/paper/714414/en

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