The relationship between ethics and religion is an important issue especially when facing with different ethical and religious perspectives. Separating religion from ethics, new concepts such as secular ethics emerges. In this field, special attention has paid to the commentary of derivation of ethics from religion which we are going to discuss about that.Our data have been collected from reliable Islamic sources from the library of the National Museum of Medical Sciences History. We also did search in the Yahoo and Google using key words such as ethics and religion, divine command theory and Islam.Taking a look at the human history shows us that in many societies religious and ethical claims have a close relationship. Controversy among Ashaere and Motazele shows the long history of the issue among Muslims. The relationship between ethics and religion can be fundamental or structural. Fundamentally, the common aims between religion and ethics and the requirement of ethics to the religion can be mentioned. In fact, both of them seek human perfection; however, human s intellect has intrinsic deficiencies. Religion compensates it by offering divine commands. In addition, regarding the wide spectrum of religious claims, religion will have an organic relationship with ethics like a tree with its trunk. For acting morally and preventing unethical actions, human beings need to be encouraged or punished. Religious comments can support and clarify ethical commands. On the other hand, with the promise of heaven and the threat of hell, people would behave morally.From theoretical point of view, there is controversy among Muslims. Ashaere don t believe in reasonable deductions and regard the religion as the only source for ethical commands. However, Moetazelis accept rational deductions as a source for ethical claims.Therefore the Theory of derivation of ethics from religion , can be evaluated from different aspects. The common aims have supportive effect on these two aspects. The ethics based on wisdom, requires religious guidance in order to compensate its limitations. The religious confirmation on the definitions of common ethics guaranties the social behavior. From theoretic point of view, there is controversy among Muslims (Ashaere and Moetazelis) as well.