The purpose of this study was to compare the physical and chemical characteristics of soils covered with vegetation and soils without vegetation in Dagh-e- Sorkh Ardestan area.To achieve the goal, first the vegetation was classified using physiognomic method, and for each vegetation type, the distinctive area was specified for soil and vegetation sampling. Vegetation sampling was done by stratified random sampling. Alongside pursuing the case, twenty two soil physical and chemical factors were investigated also for each growth type and area without vegetation. In the next step, to investigate the similarities and dissimilarities of the soils of desert areas by means of PC-ORD software, the cluster analysis was performe. After simplifying the one-way ANOVA, the most important soil factors which were effective in causing differences in the area’s soils were identified. Results show that the soils of area covered with vegetation differed much from the soils without vegetation physically in such a way that, the soil texture became heavier and gravel percentage became less in the areas without vegetation. Regarding the chemical characteristics, the frequencies of sodium, magnesium, calcium and chlorines and electrical conductivity were highly different. Because of topographic condition of land without vegetation, runoff is directed to this place and deposits salts there. Also, high groundwater level and capillary flowing salts are the important reasons for the salinity of this place. These are the limiting factors for the vegetation establishment in the desert areas of Ardestan.