COPPER-CATALYZED COUPLING REACTIONS ARE IMPORTANT TOOLS FOR THE CONSTRUCTION OF CARBONHETEROATOM BONDS.1 SEVERAL COPPER-CATALYZED REACTIONS HAVE BEEN REPORTED FOR C (ARYL) -N, C (ARYL) -O, AND C (ARYL) -S BOND FORMATION. FORMATION OF C-N BONDS REPRESENTS A KEY STEP IN THESYNTHESIS OF ORGANIC COMPOUNDS…..

BACKGROUND: PYRIMIDINE DERIVATIVES HAVE OCCUPIED AN IMPORTANT POSITION IN NATURAL AND SYNTHETIC ORGANIC CHEMISTRY, DUE TO THEIR WIDE RANGE OF BIOLOGICAL ACTIVITIES PARTICULARLY IN CANCER AND VIRUS RESEARCHES [1]. HEREIN WE REPORT A FACILE AND IMPROVED PROTOCOL FOR PREPARATION OF PYRIMIDINONE DERIVATIVES VIA THREECOMPONENT REACTION OF ALDEHYDES, N-UNSUBSTITUTEDAMIDINES, AND ETHYL CYANOACETATE UNDER THERMAL AQUEOUS CONDITIONS IN THE PRESENCE OF BISMUTH NITRATE PENTAHYDRATE AS CATALYST. (SCHEME 1).

FIVE MEMBERED LACTAMS HAVE BEEN USED SUCCESSFULLY IN ROUTES TO VARIOUS ALKALOIDS AND ARE SUITABLE PRECURSORS FOR UNUSUAL G-AMINO ACIDS SUCH AS STATINE AND ITS ANALOGUES.3-PYRROLIN-2-ONES ARE ALSO IMPORTANT STRUCTURAL UNITS OF THE RELATED INDOLOCARBAZOLE ALKALOIDS...

AMIDINES 1 COULD BE WELL-FITTED FOR THESE CRITERIA SINCE THEY ARE PROMINENT STRUCTURAL MOTIFS IN NUMEROUS BIOACTIVE NATURAL PRODUCTS. 2FURTHERMORE, THEY SERVE AS PHARMACOPHORES, SYNTHETIC INTERMEDIATES, AND EFFICIENT COORDINATING LIGANDS. THE BENZAMIDINE VARIANT IS OFTEN EMPLOYED AS AN....

AMIDINES COULD BE WELLFITTED FOR THESE CRITERIA SINCE THEY ARE PROMINENT STRUCTURAL MOTIFS IN NUMEROUS BIOACTIVE NATURAL PRODUCTS. FURTHERMORE, THEY SERVE AS PHARMACOPHORES, SYNTHETIC INTERMEDIATES, AND EFFICIENT COORDINATING LIGANDS. THE BENZAMIDINE VARIANT IS OFTEN EMPLOYED AS AN EXCELLENT GUANIDINE SURROGATE IN MEDICINAL CHEMISTRY [1, 2]. ...

INTRODUCTION FORMAMIDINES, A CLASS OF AMIDINES, HAVE APPLICATIONS IN VARIOUS FIELDS. SCIENTIST WERE INTERESTED IN SYNTHESIS AND SPECTROSCOPIC STUDY OF SOME N-CONTAINING LIGANDS SUCH AS TRIAZENES AND THEIR COMPLEX [1, 2]. IN PRESENT WORK MOLECULAR STRUCTURE OF N- (2-ETHXOYPHENYL) FORMAMIDE WERE CALCULATED BY B3LYP METHOD WITH 6-31+G (D) BASIS SET THEN COMPARED WITH EXPERIMENTAL DATA...