Bioresorbable nano stents represent a revolutionary advancement in the field of interventional cardiology, offering a novel approach to address the challenges associated with traditional stent technologies. These innovative devices are designed to provide temporary structural support to blood vessels during the critical healing phase following interventions, such as angioplasty. The key feature of bioresorbable nano stents lies in their ability to gradually degrade over time, aligning with the natural healing processes of the body. Nanotechnology plays a pivotal role in the development of bioresorbable nano stents, allowing for precise control over material properties, degradation kinetics, and biocompatibility. The customization afforded by nanomaterials enables tailoring stent characteristics to match the specific needs of individual patients and diverse clinical scenarios. This level of customization contributes to enhanced safety, reduced risk of complications, and improved patient outcomes. The controlled degradation of bioresorbable nano stents eliminates the long-term presence of foreign materials in the body, potentially mitigating late complications associated with permanent stents, such as in-stent restenosis and thrombosis. This abstract explores the potential benefits of bioresorbable nano stents, including their role in minimizing inflammatory responses and adverse reactions. In addition, the integration of nanotechnology enables the incorporation of imaging agents, antimicrobial coatings, and other functionalities, further expanding the capabilities of these innovative medical devices. The dynamic nature of nanomedicine, coupled with interdisciplinary collaboration, continues to drive advancements in bioresorbable nano stents, positioning them as a transformative technology in the landscape of cardiovascular interventions.

Objective(s): Bioresorbable scaffolds have been advocated as the new generation in interventional cardiology because they could provide temporary scaffolds and then disappear with resorption. Although, the available stents in clinical trials exhibited biosafety, efficacy, no death, and no apparent thrombosis, Mg-substrate degradation on drug release has not been investigated. Materials and Methods: Therefore, more research has been needed to legitimize the replacement of current stents with Mg-based stents. UV-Vis spectrophotometer, scanning electron microscope (SEM), X-ray diffraction (XRD), pH measurement, H₂ evolution, and corrosion tests determined the change in hybrid properties and drug release rate. Results: The effect of Mg degradation on drug release from poly-L-lactide (PLLA) specimen was much higher than that of the L605/PLLA sample. Hydrogen evolution caused by magnesium degradation compelled everolimus out without significant PLLA decomposition during the first 100 days, while formation of Mg(OH)2 caused the PLLA to deform and crack. Conclusion: A combined mechanism of lattice/hole diffusion-dissolution governed the release of everolimus with the activation energies of 5. 409 kJ/mol and 4. 936 kJ/mol for the first 24 hr and diffusion coefficients 6. 06×10-10 and 3. 64×10-11cm2/s for the 50th to 100th days. Prolonged suppression of hyperplasia within the smooth muscle cells by hybrid stent insertion could bring about the cessation of restenosis.

Postoperative abdominal adhesions are one of the most common post-laparotomy complications observed. Several types of adhesion preventative agents are available and their effectiveness and adverse impact have been clinically evaluated in previous studies. However, few basic studies have tested whether those agents do not trigger any unwanted xenobiotic reaction, which makes some surgeons hesitant to use them. To clarify this point, we investigated whether the adhesion preventative agent SeprafilmÒ (KAKEN PHARMACEUTICAL CO., LTD., Tokyo, Japan), one of the most widely used hyaluronate based bioresorbable membrane (HBBM), can trigger an inflammatory response in normal abdominal tissue and delay the healing process. The rat underwent laparotomy and a HBBM was placed directly below the incision. Tissue samples at the incision and away from the incision (normal tissue) were harvested and inflammatory response and fibrosis were evaluated using quantitative PCR and histological scoring. We found that HBBM did not induce inflammatory cytokine expression at mRNA level in the peritoneal wall tissue or modify the fibrosis process in the abdominal cavity. These findings confirm the safety of using HBBM for the prevention of adhesion development post-laparotomy.

Objective: Bioresorbable and titanium plates/screws are considered as a standard treatment for fixation of the bone segments of craniofacial area and paying attention to their biocompatibility is an important issue along with other aspects of application. The purpose of the study was to evaluate the cell viability of two types of plate and screw used in maxillofacial surgeries in contact with gingival fibroblasts and bone marrow stem cells. Materials and Methods: In this experimental study after extraction and cultivation of cells from healthy human gingival tissue and alveolar bone of jaw, cytotoxicity of device was evaluated. In direct contact method, samples had near vicinity contact with the both cell lines and in indirect contact method, by-products released, like ions, from samples after 8 weeks were used to assess cytotoxicity. Then cytotoxicity was evaluated on the 2nd, 4th and 6th day with MTS tests and microscopy. The data were analyzed by one-way ANOVA and independent t tests. Results: There was a statistically significant difference between the German plate and screw and all the samples studied on day 6 (P<0. 05). Furthermore, a statistically significant difference was observed between both metal samples and both bio-absorbable samples on day 6 and both cell lines (P<0. 05). Comparisons between the two groups with each other for both cell lines on the 6th day were statistically significant (P<0. 05). Conclusion: Our results suggest that that cytotoxicity of biomaterial, from different brands, were not similar and some of the biomaterial showed lower degree of toxicity compared to others and specialist using these products showed be aware of this differences. Our investigation indicates more biocompatibility of bioresorbable plates and screws compared to titanium. In addition our results suggest that biomaterials were not completely neutral.

China’s rapid transition into a super-aged society is accelerating demand for advanced wearable healthcare sensors tailored for long-term, low-burden monitoring. While numerous reviews discuss demographic and policy contexts, fewer highlight the latest wearable sensor research emerging from Chinese laboratories and companies. This Mini Review summarizes representative advances published in the last five years across three major application areas—chronic metabolic disease management, neurodegenerative disease monitoring, and cardiovascular risk mitigation—focusing on sensor design, sampling media, data integration, and clinical relevance. Rather than examining demographic trends or general market growth, we emphasize technological breakthroughs such as non-invasive glucose-sensing microneedle patches, CKD-oriented urine/breath analyzers, multimodal gait–EEG neurodegenerative platforms, and bioresorbable cardiovascular implants that reflect China's emphasis on long-term, low-burden, and telemedicine-ready care. By concentrating on these China-originated devices and research prototypes, this review aims to provide a concise update on emerging concepts and highlight how these technologies reflect localized priorities—such as non-invasive sampling and family-assisted tele-care—while shaping future global trends.