To evaluate the effect of nitrogen and water withholding in vegetative growth stage of corn on efficacy of nicosulfuron and 2,4-D+ MCPA an experiment was conducted as a factorial arrangement in a randomized complete block design with three replications at Tarbiat Modares University in 2017. The first factor contained four treatments including application of nicosulfuron, 2,4-D+ MCPA, weed free and weed infested as control. The second factor consisted of normal irrigation and water withholding from 4 to 8 leaf stage. Third factor contained either urea application or no fertilizer application. Normal irrigation and nitrogen fertilizer application significantly increased nicosulfuron and 2,4-D+ MCPA efficacy in weed control and total weed dry weight decreased to 341 and 361 g.m-2 respectively compared 1370 g.m-2 as weed infested. Nicosulfuron and 2,4-D+ MCPA reduced weed total dry weight significantly under irrigation withholding. Grain yield increased with application of nitrogen and nicosulfuron. Grain yield was higher with application of 2,4-D+ MCPA than nicosulfuron without nitrogen application under irrigation withholding. Application of nicosulfuron with nitrogen application provided satisfactory weed control and increased grain yield.