In the veterinary texts of the Islamic period, we frequently encounter the word Qeysar, which is an animal disease and specially has been well described in horses. It is characterized by muscular contractions, the retraction of the third eyelid, dysphasia and other symptoms that have been mentioned in the veterinary literature of Islamic period manuscripts. Considering these symptoms and some evident similarities, we have tried in this study to compare Qeysar with Tetanus. Our methods are etymological and historical studies of these three words (Qeysar, Kozaz and Tetanus), in classical Arabic, Persian and also western (Roman and Greek) sources. According our knowledge, this is the first scientific study of Qeysar in the view point of pathology and ETIMOLOGY of this disease.