Following day was a national holiday <HTTP://en.wikipedia.org/wiki/Vernal_equinox>. The attack came at the peak of the Monday morning rush hour on one of the world's busiest commuter transport systems. The Tokyo subway system transports millions of passengers daily; during rush hour, trains are frequently so crowded that it is nearly impossible to move. The liquid sarin <HTTP://en.wikipedia.org/wiki/Sarin> was contained in plastic bags which each team then wrapped in newspapers. Each perpetrator carried two packets of sarin totalling approximately one litre <HTTP://en.wikipedia.org/wiki/Litre> of sarin, except Yasuo Hayashi, who carried three bags. A single drop of sarin the size of the head of a pin can kill an adult. Carrying their packets of sarin and umbrellas with sharpened tips, the perpetrators boarded their appointed trains; at prearranged stations, each perpetrator dropped his package and punctured it several times with the sharpened tip of his umbrella before escaping to his accomplice's waiting get-away car. Sarin is an extremely potent organophosphate <HTTP://en.wikipedia.org/wiki/Organophosphate> compound that disrupts the nervous system by inhibiting the cholinesterase enzyme by forming a covalent bond <HTTP://en.wikipedia.org/wiki/Covalent_bond> with the particular serine <HTTP://en.wikipedia.org/wiki/Serine> residue in the enzyme which forms the site where acetylcholine normally undergoes hydrolysis <HTTP://en.wikipedia.org/wiki/Hydrolysis>. The short- and long-term symptoms experienced by those affected included: bleeding <HTTP://en.wikipedia.org/wiki/Blood> from the nose and mouth, coma <HTTP://en.wikipedia.org/wiki/Coma>, convulsions <HTTP://en.wikipedia.org/wiki/Convulsion>, difficulty breathing <HTTP://en.wikipedia.org/wiki/Difficulty_breathing>, disturbed sleep 2and nightmares <HTTP://en.wikipedia.org/wiki/Nightmare>, extreme sensitivity to ligh, foaming at the mouth, high fevers <HTTP://en.wikipedia.org/wiki/Fever>, influenza <HTTP://en.wikipedia.org/wiki/Influenza>-like symptoms, loss of consciousness <HTTP://en.wikipedia.org/wiki/Loss_of_consciousness>, loss of memory <HTTP://en.wikipedia.org/wiki/Loss_of_memory>, nausea <HTTP://en.wikipedia.org/wiki/Nausea> and vomiting <HTTP://en.wikipedia.org/wiki/Vomiting>, paralysis <HTTP://en.wikipedia.org/wiki/Paralysis>, post-traumatic stress disorder <HTTP://en.wikipedia.org/wiki/Post-traumatic_stress_disorder>, respiratory problems, seizures <HTTP://en.wikipedia.org/wiki/Seizure>, uncontrollable, trembling <HTTP://en.wikipedia.org/wiki/Trembling>, vision problems both temporary and permanent.

Anxiety is an unpleasant emotional state that involves a complex combination of emotions that include fear <HTTP://en.wikipedia.org/wiki/Fear>, apprehension <HTTP://en.wikipedia.org/wiki/Apprehension>, and worry <HTTP://en.wikipedia.org/wiki/Worry>. It is often accompanied by physical sensations such as heart palpitations <HTTP://en.wikipedia.org/wiki/Heart_palpitations>, nausea <HTTP://en.wikipedia.org/wiki/Nausea>, chest pain <HTTP://en.wikipedia.org/wiki/Chest_pain>, shortness of breath <HTTP://en.wikipedia.org/wiki/Shortness_of_breath>, or tension headache <HTTP://en.wikipedia.org/wiki/Tension_headache>. Valerian has uses in herbal <HTTP://en.wikipedia.org/wiki/Herb> medicine as a sedative <HTTP://en.wikipedia.org/wiki/Sedative>. Studies shown efficacy of valerian as a treatment for insomnia. The purpose of this study was to characterize the putative anxiolytic-like effects of valepotriates (dichloromethane extracts of valerian) using the elevated plus maze (EPM) in rats. valepotriates was dissolved in DMSO and orally administered at doses from 0.025 to 1 g/kg to adult male wistar rats , 0.5 , 1.5 and 3 hours before behavioral evaluation in an EPM respectively. Control rats were treated with an equal volume of DMSO. Single treatment of valepotriates (at 0.025, 0.0.05, 0.1, and 0.2 g/kg) significantly increased time-spent and arm entries into open arms of EPM versus control groups (p<0.05). However, no changes in the locomotor activity . This result suggest that valepotriates might proved to be an effective anxiolytic agent.

Introduction: Syrian Rue with scientific name Peganum harmala L. belong s to Zygophyllaceae family is an annual and flowers are in September. Dry steppes, especially where grazing is heavy and dry waste places. in traditional used that are digestive, diuretic, uterine stimulant, emmenagogue <HTTP://www.pfaf.org/database/search_use.php?K%5b%5d=Emmenagogue> , galactogogue <HTTP://www.pfaf.org/database/search_use.php?K%5b%5d=Galactogogue>, aphrodisiac <HTTP://www.pfaf.org/database/search_use.php?K%5b%5d=Aphrodisiac>, narcotic <HTTP://www.pfaf.org/database/search_use.php?K%5b%5d=Narcotic>, epilepsy, parasiticide <HTTP://www.pfaf.org/database/search_use.php?K%5b%5d=Parasiticide>, cold, fever, rheumatic, mental and nervous illnesses. There for with attention to wild dispersal in rangetands of this North Eastern Golestan.Methods: there for with attention to good adaptation and wild dispersal in many grazing of this province we decided to extraction ethanol and antibacterial effects of this plant by disc diffusion and well methods against infect UTI From golstan prevalence.Results: This study showed that in well methods have good effected for bacteria. Antibacterial effect on Pseudomonas aeruginosa was more than Escherichia coli, Klebciella pneumonia, Acintobacter.