Introduction: Exercise is a promising non-pharmacological option to potentially delay the onset or slow the progression of Alzheimer's disease. Therefore, this research seeks to find the possible mechanism of the connection between muscle and hippocampus under the influence of swimming exercise in rats with Alzheimer's disease. The significance level was 0.05. Materials and Methods: Thirty-two 6-week-old rats were randomly divided into four groups: sham (SH), Alzheimer's control (AC), training (T) and Alzheimer's training (AT). Alzheimer's was induced by injecting beta-amyloid into the hippocampus. The training program consisted of 20 swimming training sessions with increasing time. After the end of the intervention, the tissue of the Gastrocnemius muscle and hippocampus was removed and the expression of the desired proteins was measured by immunohistofluorescent staining method. A correlation test was used to check the changes of the studied indicators. Results: The results showed that the expression of neuron cell adhesion molecule, SEMA3A and profilins proteins had a significant positive relationship with NACHRa7 (P=0.001) and a significant inverse relationship with NLRP1 (P≥0.05) and Dead Cells (P≥0.05). Conclusion: It seems that the induction of Alzheimer's causes the destruction of the neuromuscular junction and motor neurons. It can be effective in increasing hippocampus inflammation, on the other hand, swimming exercises is an effective intervention to improve axonal regeneration and neuron plasticity in motor neurons, and therefore it can be an effective intervention to prevent and control the complications of Alzheimer's disease in old age.