Purpose: To report the anatomical and functional outcomes of Retinotomy and/or retinectomy for the management of rhegmatogenous retinal detachment (RRD) complicated by advanced proliferative vitreoretinopathy (PVR). Methods: In this retrospective study, the charts of patients who underwent pars plana vitrectomy with Retinotomy and/or retinectomy for the management of RRD complicated by PVR were reviewed. Primary outcome measures were final best-corrected visual acuity (BCVA) and anatomical reattachment rate. Results: Sixty-one eyes of 61 patients with a mean age of 48. 56 ±,15. 92 were studied. The mean follow-up time was 21. 38 ±,23. 08 months. The mean angle of the Retinotomy was 171. 31°,±,79. 15°, . Thirty-two (52. 5%) of them needed extensive (≥, 180°, ) Retinotomy. In addition, simultaneous retinectomy was performed in 36. 2% of the cases. The BCVA was 2. 18 ±,0. 63 and 1. 85 ±,0. 71 logMAR before the surgery and at the last visit, respectively (P = 0. 001). The initial anatomical success was achieved in 45 eyes (73. 8%) after Retinotomy surgery. Sixteen eyes (26. 2%) had recurrent RD and needed reoperation, which was performed 5. 60 ±,4. 01 months after the initial Retinotomy surgery. At the last examination, the retina was attached in all patients. Conclusion: Retinotomy with/without retinectomy is an effective procedure in the majority of patients with RRD associated with advanced PVR,however, additional surgeries are needed in a significant number of eyes to achieve final anatomical success.